Results 121 to 130 of about 3,164,214 (296)

F(R) Gravity’s Rainbow and Its Einstein Counterpart

open access: yesAdvances in High Energy Physics, 2016
Motivated by UV completion of general relativity with a modification of a geometry at high energy scale, it is expected to have an energy dependent geometry.
S. H. Hendi   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Invariant Solutions for a Class of Perturbed Nonlinear Wave Equations

open access: yes, 2017
Approximate symmetries of a class of perturbed nonlinear wave equations are computed using two newly-developed methods. Invariant solutions associated with the approximate symmetries are constructed for both methods. Symmetries and solutions are compared
F. D. Zaman   +4 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Homoclinic solutions to invariant tori in a center manifold

open access: yes, 2008
We consider an autonomous, second order Hamiltonian system having a saddle-center stationary point whose center manifold is foliated in invariant tori and we prove existence of infinitely many solutions asymptotic, as time goes to +∞ and -∞ to some of ...
COTI ZELATI, VITTORIO   +5 more
core   +2 more sources

Reductions and conservation laws for BBM and modified BBM equations

open access: yesOpen Mathematics, 2016
In this paper, the classical Lie theory is applied to study the Benjamin-Bona-Mahony (BBM) and modified Benjamin-Bona-Mahony equations (MBBM) to obtain their symmetries, invariant solutions, symmetry reductions and differential invariants. By observation
Khorshidi Maryam   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

The Liapunov Center Theorem for a Class of Equivariant Hamiltonian Systems

open access: yesAbstract and Applied Analysis, 2012
We consider the existence of the periodic solutions in the neighbourhood of equilibria for 𝐶∞ equivariant Hamiltonian vector fields. If the equivariant symmetry 𝑆 acts antisymplectically and 𝑆2=𝐼, we prove that generically purely imaginary eigenvalues ...
Jia Li, Yanling Shi
doaj   +1 more source

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