Results 101 to 110 of about 546,512 (289)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Existence, stability and the number of two-dimensional invariant manifolds for the convective Cahn–Hilliard equation

open access: yesPartial Differential Equations in Applied Mathematics
We study the well-known generalised version of the nonlinear Cahn–Hilliard evolution equation, supplemented with periodic boundary conditions. We study local bifurcations in the vicinity of spatially homogeneous equilibrium states.
A.N. Kulikov, D.A. Kulikov
doaj   +1 more source

Reductions and conservation laws for BBM and modified BBM equations

open access: yesOpen Mathematics, 2016
In this paper, the classical Lie theory is applied to study the Benjamin-Bona-Mahony (BBM) and modified Benjamin-Bona-Mahony equations (MBBM) to obtain their symmetries, invariant solutions, symmetry reductions and differential invariants. By observation
Khorshidi Maryam   +3 more
doaj   +1 more source

Invariant Subspace and Classification of Soliton Solutions of the Coupled Nonlinear Fokas-Liu System

open access: yesFrontiers in Physics, 2019
In this work, the coupled nonlinear Fokas-Liu system which is a special type of KdV equation is studied using the invariant subspace method (ISM). The method determines an invariant subspace and construct the exact solutions of the nonlinear partial ...
Aliyu Isa Aliyu   +3 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

The Liapunov Center Theorem for a Class of Equivariant Hamiltonian Systems

open access: yesAbstract and Applied Analysis, 2012
We consider the existence of the periodic solutions in the neighbourhood of equilibria for 𝐶∞ equivariant Hamiltonian vector fields. If the equivariant symmetry 𝑆 acts antisymplectically and 𝑆2=𝐼, we prove that generically purely imaginary eigenvalues ...
Jia Li, Yanling Shi
doaj   +1 more source

Lorentz invariant vacuum solutions in general relativity [PDF]

open access: yesProceedings of the Steklov Institute of Mathematics, 2015
5 ...
openaire   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

INVARIANT FUNDAMENTAL SOLUTION OF THE WAVE OPERATOR

open access: yesDemonstratio Mathematica, 1986
We present a method for determining a fundamental solution of the wave operator \(\square_ n=\partial^ 2/\partial t^ 2- \sum^{n}_{j=1}\partial^ 2/\partial x^ 2_ j\) for an arbitrary \(n\geq 1\) which, as we think, is simpler than other methods used up to now.
Szmydt, Zofia, Ziemian, Bogdan
openaire   +1 more source

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