Results 81 to 90 of about 38,572 (218)

Symmetries, travelling-wave and self-similar solutions of two-component BKP hierarchy

Alexandria Engineering Journal
We investigate the two-component BKP hierarchy equation for its Lie point symmetries. To obtain a complete classification of the group-invariant solution, we derive the one-dimensional optimal system of subalgebras of A3,3(D⨂sT2).
J. Mohammed Zubair Ahamed, R. Sinuvasan
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Multiple solutions for parametric weighted (p,q)-equations

Electronic Journal of Differential Equations
In this article, we prove that equations driven by a weighted (p,q)-Laplacian have at least two positive solutions, two negative solutions, and two sign-changing solutions.
Xiaohui Zhang, Xian Xu
doaj  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Multiple symmetric solutions for a singular semilinear elliptic problem with critical exponent

Electronic Journal of Differential Equations, 2012
Let be $Gamma$ a closed subgroup of $O(N)$. We consider the semilinear elliptic problem $$displaylines{ -Delta u-frac{b(x)}{| x|^2}u-a(x)u=f(x)| u|^{2^{ast }-2}uquad hbox{in }Omega ,cr u=0 quadhbox{on } partial Omega , }$$ where $Omega subset ...
Alfredo Cano, Eric Hernandez-Martinez
doaj  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Nonlinear self-adjointness and invariant solutions of a 2D Rossby wave equation

Open Physics, 2014
Cimpoiasu Rodica, Constantinescu Radu
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Constant invariant solutions of the Poincare center-focus problem

Electronic Journal of Differential Equations, 2010
We consider the classical Poincare problem $$ frac{dx}{dt}=-y-p(x,y),quad frac{dy}{dt}=x+q(x,y) $$ where $p,q$ are homogeneous polynomials of degree $n geq 2$.
Gary R. Nicklason
doaj