Results 61 to 70 of about 38,572 (218)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

ON SYMMETRY REDUCTIONS AND INVARIANT SOLUTIONS OF THE k-ε TURBULENCE MODEL

Научный вестник МГТУ ГА, 2016
Methods of theoretical group analysis of differential equations are applied to the k -ε turbulence model. Symmetry reductions of the k -ε turbulence model with respect to some three-dimensional symmetry subalgebras are considered.
N. G. Khor'kova
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Existence, stability and the number of two-dimensional invariant manifolds for the convective Cahn–Hilliard equation

Partial Differential Equations in Applied Mathematics
We study the well-known generalised version of the nonlinear Cahn–Hilliard evolution equation, supplemented with periodic boundary conditions. We study local bifurcations in the vicinity of spatially homogeneous equilibrium states.
A.N. Kulikov, D.A. Kulikov
doaj   +1 more source

Reductions and conservation laws for BBM and modified BBM equations

Open Mathematics, 2016
In this paper, the classical Lie theory is applied to study the Benjamin-Bona-Mahony (BBM) and modified Benjamin-Bona-Mahony equations (MBBM) to obtain their symmetries, invariant solutions, symmetry reductions and differential invariants. By observation
Khorshidi Maryam, Nadjafikhah Mehdi, Jafari Hossein, Al Qurashi Maysaa   +3 more
doaj   +1 more source

Invariant Subspace and Classification of Soliton Solutions of the Coupled Nonlinear Fokas-Liu System

Frontiers in Physics, 2019
In this work, the coupled nonlinear Fokas-Liu system which is a special type of KdV equation is studied using the invariant subspace method (ISM). The method determines an invariant subspace and construct the exact solutions of the nonlinear partial ...
Aliyu Isa Aliyu, Yongjin Li, Dumitru Baleanu, Dumitru Baleanu   +3 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Liapunov Center Theorem for a Class of Equivariant Hamiltonian Systems

Abstract and Applied Analysis, 2012
We consider the existence of the periodic solutions in the neighbourhood of equilibria for 𝐶∞ equivariant Hamiltonian vector fields. If the equivariant symmetry 𝑆 acts antisymplectically and 𝑆2=𝐼, we prove that generically purely imaginary eigenvalues ...
Jia Li, Yanling Shi
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source