Results 51 to 60 of about 38,572 (218)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Group Classification and Symmetry Reduction of a (1+1)-Dimensional Porous Medium Equation

AppliedMath
In this paper, we present Lie symmetry analysis of a generalized (1+1)-dimensional porous medium equation characterized by parameters m and d. Through group classification, we examine how these parameters influence the Lie symmetry structure of the ...
Polokwane Charles Makibelo, Winter Sinkala, Lazarus Rundora   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Reaction–Diffusion on the Sphere with a Nonlinear Source Term: Symmetry Analysis, Group Classification, and Similarity Solutions

Mathematics
We consider the nonlinear reaction–diffusion equation on the unit sphere ut=ΔS2u+f(u), fuu≠0, and carry out a complete Lie point symmetry analysis. Solving the associated determining system yields a rigidity theorem: for every genuinely nonlinear f(u ...
Khalid Ali Alanezy
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Forward Euler Solutions and Weakly Invariant Time-Delayed Systems

Abstract and Applied Analysis, 2012
This paper presents a necessary and sufficient condition for the weak invariance property of a time-delayed system parametrized by a differential inclusion.
Norma L. Ortiz-Robinson, Vinicio R. Ríos   +1 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Invariance properties of the microstrain wave equation arising in microstructured solids

Results in Physics
The Lie group method stands as a significant, powerful, and straightforward mathematical tool for discovering precise invariant solutions and traveling wave solutions in prevalent nonlinear evolution equations across engineering, applied mathematics, and
Muhammad Usman, Akhtar Hussain, Ahmed M. Zidan, Abdullah Mohamed   +3 more
doaj   +1 more source

F(R) Gravity’s Rainbow and Its Einstein Counterpart

Advances in High Energy Physics, 2016
Motivated by UV completion of general relativity with a modification of a geometry at high energy scale, it is expected to have an energy dependent geometry.
S. H. Hendi, B. Eslam Panah, S. Panahiyan, M. Momennia   +3 more
doaj   +1 more source