Results 21 to 30 of about 304,649 (268)

Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer—insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Breast Cancer Research, 2020
Background Breast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integrins/integrin-linked kinase signalling are upregulated.
Razan Wafai, Elizabeth D. Williams, Emma de Souza, Peter T. Simpson, Amy E. McCart Reed, Jamie R. Kutasovic, Mark Waltham, Cameron E. Snell, Tony Blick, Erik W. Thompson, Honor J. Hugo   +10 more
doaj   +1 more source

Circular RNA circTRIM33–12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression

Molecular Cancer, 2019
Background Recently, the dysregulation of circular RNA (circRNA) have been shown to have important regulatory roles in cancer development and progression, including hepatocellular carcinoma (HCC).
Peng-Fei Zhang, Chuan-Yuan Wei, Xiao-Yong Huang, Rui Peng, Xuan Yang, Jia-Cheng Lu, Chi Zhang, Chao Gao, Jia-Bin Cai, Ping-Ting Gao, Dong-Mei Gao, Guo-Ming Shi, Ai-Wu Ke, Jia Fan   +13 more
doaj   +1 more source

Size-dependent functional response of Xenopus laevis feeding on mosquito larvae [PDF]

PeerJ, 2018
Predators can play an important role in regulating prey abundance and diversity, determining food web structure and function, and contributing to important ecosystem services, including the regulation of agricultural pests and disease vectors.
Corey J. Thorp, Mhairi E. Alexander, James R. Vonesh, John Measey   +3 more
doaj   +2 more sources

Contribution of 3q26-29 gene cluster to glioma invasion [PDF]

, 2015
Diffuse gliomas are the most common and lethal brain tumors. Cell invasion into the surrounding brain tissue is a hallmark feature of glioma. Understanding the mechanism of glioma invasion could lead to the discovery of novel therapeutic strategies to ...
Ramadoss, Archana
core   +1 more source

Use of non-timber forest products from invasive alien Prosopis species (mesquite) and native trees in South Africa: implications for management

Forest Ecosystems, 2015
Background Prosopis species have been introduced to many areas outside their native range to provide benefits to local communities. Several Prosopis species and their hybrids (hereafter “mesquite”) have, however, become naturalised and invasive and now ...
Ross T Shackleton, David C Le Maitre, Brian W van Wilgen, David M Richardson   +3 more
doaj   +1 more source

GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer

Signal Transduction and Targeted Therapy, 2023
In the treatment of most malignancies, radiotherapy plays a significant role. However, the resistance of cancer cells to ionizing radiation (IR) is the main reason for the failure of radiotherapy, which causes tumor recurrence and metastasis.
Yao Long, Jiaxing Guo, Jielin Chen, Jingyue Sun, Haiyan Wang, Xin Peng, Zuli Wang, WeiWei Lai, Na Liu, Long Shu, Ling Chen, Ying Shi, Desheng Xiao, Shuang Liu, Yongguang Tao   +14 more
doaj   +1 more source

CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma

Cell Death and Disease, 2022
As the first rate-limiting enzyme in fatty acid oxidation (FAO), CPT1 plays a significant role in metabolic adaptation in cancer pathogenesis. FAO provides an alternative energy supply for cancer cells and is required for cancer cell survival.
Min Tang, Xin Dong, Lanbo Xiao, Zheqiong Tan, Xiangjian Luo, Lifang Yang, Wei Li, Feng Shi, Yueshuo Li, Lin Zhao, Na Liu, Qianqian Du, Longlong Xie, Jianmin Hu, Xinxian Weng, Jia Fan, Jian Zhou, Qiang Gao, Weizhong Wu, Xin Zhang, Weihua Liao, Ann M. Bode, Ya Cao   +22 more
doaj   +1 more source

Insights into invasion and restoration ecology : time to collaborate towards a holistic approach to tackle biological invasions [PDF]

, 2012
The aim of our study is to provide an integrated framework for the management of alien plant invasions, combining insights and experiences from the fields of invasion and restoration ecology to enable more effective management of invasive species.
Mirijam Gaertner, Gaertner,Mirijam, Esler,Karen, Gaertner, Mirijam, Sharma, Gyan P., Sharma, Gyan, Fisher,Judith, Fisher, Judy L., Fisher, Judith, Sharma,Gyan, Esler, Karen J., Judith Fisher, Esler, Karen, Gyan Sharma, Karen Esler   +14 more
core   +1 more source

The dark web trades wildlife, but mostly for use as drugs

People and Nature, 2023
Contemporary wildlife trade is massively facilitated by the Internet. By design, the dark web is one layer of the Internet that is difficult to monitor and continues to lack thorough investigation.
Oliver C. Stringham, Jacob Maher, Charlotte R. Lassaline, Lisa Wood, Stephanie Moncayo, Adam Toomes, Sarah Heinrich, Freyja Watters, Charlotte Drake, Sebastian Chekunov, Katherine G. W. Hill, David Decary‐Hetu, Lewis Mitchell, Joshua V. Ross, Phillip Cassey   +14 more
doaj   +1 more source

Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/β-catenin positive feedback loop

Journal of Experimental & Clinical Cancer Research, 2020
Background Sustained adrenergic signaling secondary to chronic stress promotes cancer progression; however, the underlying mechanisms for this phenomenon remain unclear.
Xia-Hui Lin, Hua-Hua Liu, Shu-Jung Hsu, Rui Zhang, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren, Rong-Xin Chen   +9 more
doaj   +1 more source