Results 61 to 70 of about 304,649 (268)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A Crab Invasion [PDF]

Science, 1885
n ...
openaire   +2 more sources

Activated hepatic stellate cells secrete periostin to induce stem cell-like phenotype of residual hepatocellular carcinoma cells after heat treatment

Scientific Reports, 2017
Some evidences show that residual tumor after thermal ablation will progress rapidly. However, its mechanisms remain unclear. Here, we assessed whether activated HSCs could regulate stem cell-like property of residual tumor after incomplete thermal ...
Rui Zhang, Rong-Rong Yao, Jing-Huan Li, Gang Dong, Min Ma, Qiong-Dan Zheng, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren, Rong-Xin Chen   +9 more
doaj   +1 more source

MiR-612 regulates invadopodia of hepatocellular carcinoma by HADHA-mediated lipid reprogramming

Journal of Hematology & Oncology, 2020
Background MicroRNA-612 (miR-612) has been proven to suppress EMT, stemness, and tumor metastasis of hepatocellular carcinoma (HCC) via PI3K/AKT2 and Sp1/Nanog signaling. However, its biological roles on HCC progression are far from elucidated.
Yang Liu, Li-Li Lu, Duo Wen, Dong-Li Liu, Li-Li Dong, Dong-Mei Gao, Xin-Yu Bian, Jian Zhou, Jia Fan, Wei-Zhong Wu   +9 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Clinical significance of preoperative serum VEGF in predicting metachronous liver metastasis of colorectal cancer: development of a novel nomogram

World Journal of Surgical Oncology
Background Metachronous liver metastasis (MLM) after primary resection of colorectal cancer (CRC) substantially worsens patient prognosis. Vascular endothelial growth factor (VEGF) is a highly bioactive proangiogenic protein.
Yufei Gu, Jin Du, Yanxin Zhao, Zhongwen Sun, Haijian Yang, Libing Yang, Zhenzhen Cao, Xintao Wang   +7 more
doaj   +1 more source

Tumor neoantigen gene C7orf50 remodels the immune microenvironment by recruiting tumor-associated macrophages to promote hepatocellular carcinoma progression and lung metastasis

Journal for ImmunoTherapy of Cancer
Background Hepatocellular carcinoma (HCC) is a global health challenge with high mortality rates, particularly in patients with advanced disease and lung metastasis.
Xiaowu Huang, Zhiqiang Hu, Yu Gong, Jia Li, Feng Qi, Hecheng Li, Li Mao, Changzhou Chen, Sheng Su, Xinming Ye, Zehuan Li   +10 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Physico-chemical variables determining the invasion risk of freshwater habitats by alien mollusks and crustaceans

, 2012
The aim of this study was to assess the invasion risk of freshwater habitats and determine the environmental variables that are most favorable for the establishment of alien amphipods, isopods, gastropods, and bivalves.
Früh, Denise, Haase, Peter, Stoll, Stefan   +2 more
core   +1 more source

Biological invasions in agricultural settings: insights from evolutionary biology and population genetics [PDF]

, 2011
Invasion biology and agriculture are intimately related for several reasons and in particular because many agricultural pest species are recent invaders. In this article we suggest that the reconstruction of invasion routes with population genetics-based
Thomas Guillemaud, Ciosi, Marc, Lombaert, Eric, Ciosi, M., Éric Lombaert, Estoup, Arnaud, Guillemaud, T., Estoup, A., Guillemaud, Thomas, Marc Ciosi, Arnaud Estoup, Guillemaud, Thomas,, Lombaert, E.   +12 more
core   +1 more source