Results 71 to 80 of about 1,781,803 (291)

Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy

Advanced Science, EarlyView.
Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song, Can Zhao, Qiaoling Wang, Hongjiao Zhang, Xiao Liu, Linqi Wang, Michael Bromley, Wen‐Bing Yin   +7 more
wiley   +1 more source

A case report on successfully treated invasive pulmonary mucormycosis in a patient with poorly controlled diabetes mellitus

Asian Journal of Internal Medicine
Although fungal infections are common in clinical practice, usually they are superficial and invasive infections are very rare among immunocompetent people.
P. Dikshaladevi, N. Selvaratnam, J. Nalayini, T. Peranantharajah   +3 more
doaj   +1 more source

Invasive Fungal Infections after Natural Disasters

Emerging Infectious Diseases, 2014
The link between natural disasters and subsequent fungal infections in disaster-affected persons has been increasingly recognized. Fungal respiratory conditions associated with disasters include coccidioidomycosis, and fungi are among several organisms ...
Kaitlin Benedict, Benjamin J. Park
doaj   +1 more source

Symbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex

Advanced Science, EarlyView.
In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun   +8 more
wiley   +1 more source

Invasive Fungal Infections [PDF]

, 2018
Invasive fungal diseases (IFD) are frequent infectious complications of HSCT. The 12 m cumulative incidence approaches 8–10% in URD or mismatched allo-HSCT, 6% in MRD allo-HSCT, and less than 2% following auto-HSCT (Kontoyiannis et al. 2010). However, higher incidences (up to 17%) have been reported in haplo-identical HSCT and CBT.
openaire   +2 more sources

Invasive fungal infections in transplant recipients [PDF]

Therapeutic Advances in Infectious Disease, 2013
Invasive fungal infections are an important cause of morbidity and mortality in hematopoietic stem cell transplant and solid organ transplant recipients. Evolving transplant modalities and techniques, complex and extensive immunosuppressant strategies, and the increased use of broad spectrum antifungal prophylaxis has greatly impacted the epidemiology ...
Jose A, Vazquez, Marisa H, Miceli, George, Alangaden   +2 more
openaire   +2 more sources

Invasive fungal infections in Chile: a multicenter study of fungal prevalence and susceptibility during a 1-year period [PDF]

, 2004
During the first year of an ongoing surveillance program of invasive fungal infections (IFI) a total of 130 patients (56% male) with fungal strains isolated from blood and other sterile sites were reported from 13 hospitals in Chile.
Díaz Jarabrán, María Cristina, Silva Vargas, Víctor, Chilean Invasive Fungal Infections Group, Febré V., Naldy   +3 more
core  

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Prevention of invasive fungal infections in immunocompromised patients: the role of delayed-release posaconazole [PDF]

, 2015
Ahmet SoysalDivision of Pediatric Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Marmara University, Istanbul, TurkeyAbstract: Posaconazole is a triazole antifungal agent that has broad-spectrum activity against many yeasts and ...
Soysal A
core  

Role of isavuconazole in the treatment of invasive fungal infections.

, 2016
Despite recent advances in both diagnosis and prevention, the incidence of invasive fungal infections continues to rise. Available antifungal agents to treat invasive fungal infections include polyenes, triazoles, and echinocandins.
Drew RH, Jones TM, Dimondi VP, DiMondi, V. P., Wilson, Dustin T, Johnson SW, Jones, T. M., Dimondi, V Paul, Drew, Richard H, Wilson, D., Drew, Richard H., Dimondi, V., Johnson, S., Wilson, D. T., Wilson DT, Drew, R. H., Jones, Travis M, Johnson, Steven W, Johnson, S. W., Jones, T.   +19 more
core   +1 more source