Results 61 to 70 of about 577,114 (263)

Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish.

PLoS Pathogens, 2022
Invasive aspergillosis is a common opportunistic infection, causing >50% mortality in infected immunocompromised patients. The specific molecular mechanisms of the innate immune system that prevent pathogenesis of invasive aspergillosis in ...
Savini Thrikawala, Mengyao Niu, Nancy P Keller, Emily E Rosowski   +3 more
doaj   +1 more source

Endophytes influence protection and growth of an invasive plant [PDF]

Communicative & Integrative Biology, 2009
We investigated the symbiotic activities of fungal endophytes isolated from spotted knapweed, Centaurea stoebe. Previously, an analysis of community similarity had demonstrated differences in the endophyte communities of C. stoebe in its native and invaded ranges. Here, we found that specific endophytes can exert positive effects on their host, whereas
George, Newcombe, Alexey, Shipunov, Sd, Eigenbrode, Anil Kh, Raghavendra, H, Ding, Cort L, Anderson, R, Menjivar, M, Crawford, M, Schwarzländer   +8 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Aggregate Filamentous Growth Responses in Yeast

mSphere, 2019
Many fungal species, including pathogens, undergo a morphogenetic response called filamentous growth, where cells differentiate into a specialized cell type to promote nutrient foraging and surface colonization.
Jacky Chow, Heather M. Dionne, Aditi Prabhakar, Amit Mehrotra, Jenn Somboonthum, Beatriz Gonzalez, Mira Edgerton, Paul J. Cullen   +7 more
doaj   +1 more source

MicroRNAs Impair MET-Mediated Invasive Growth [PDF]

Cancer Research, 2008
Abstract MicroRNAs (miRNA) are a recently identified class of noncoding, endogenous, small RNAs that regulate gene expression, mainly at the translational level. These molecules play critical roles in several biological processes, such as cell proliferation and differentiation, development, and aging. It is also known that miRNAs play
Migliore, C., Petrelli, A., Ghiso, E., Corso, S., Capparuccia, L., Eramo, A., Comoglio, P. M., Giordano, S.   +7 more
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Nucleobindin-2 Promotes the Growth and Invasion of Glioblastoma [PDF]

Cancer Biotherapy and Radiopharmaceuticals, 2019
Background: Glioblastoma is one of the most malignant tumors in the brain with high mortality. In recent years, immunotherapy and targeted therapy show great prospects in the treatments for glioblastoma, whereas more effective therapeutic targets are still urgently needed to be developed.
Qing-Jun, Liu, Jia-Xi, Lv, Jun, Liu, Xue-Bin, Zhang, Lei-Bo, Wang   +4 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The prevalence of obesity and overweight among Iranian population: an umbrella systematic review and meta-analysis

BMC Public Health
Background The present umbrella systematic reviews and meta-analyses aim to determine the comprehensive prevalence of obesity and overweight across different age subgroups in Iran.
Azadeh Dehghani, Roghayeh Molani-Gol, Maryam Mohammadi-Narab, Abdolreza Norouzy, Mohammad Hassan Abolhassani, Seyed Mohammad Tabatabaee Jabali, Abdolreza Pazouki, Fahimeh Soheilipour, Fatemeh Mohammadi-Nasrabadi   +8 more
doaj   +1 more source