Results 91 to 100 of about 86,777 (263)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Effects of nano oxide particles on the growth and photosynthetic characteristics of okra plant under water deficiency

Folia Horticulturae
Drought, as abiotic stress, has significant detrimental effects on the growth, physiology, yield and nutritional quality of plants. The distinctive characteristics of nanoparticles (NPs) significantly contribute to essential physiological processes ...
Wang Jiyue, Xu Jiajun, Xie Rongrong, Chen Nian, Yang Mingli, Tian Xiaojian, Shi Denghong   +6 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evidence of kinship, overwintering, and Wolbachia presence in Aedes albopictus in urban areas and points of entry in the Netherlands

Parasites & Vectors
Background The Asian tiger mosquito, Aedes albopictus, is an aggressive invasive vector responsible for transmitting important arboviruses. Its global spread has been largely facilitated by human-mediated transport, especially through trade and road ...
Adolfo Ibáñez-Justicia, Federica Lucati, Paulina Maria Lesiczka, Tim Warbroek, Vicente J. Ontiveros, Jenny Caner, Rubén Bueno-Marí, Carles Aranda, Alessandro Albieri, Bart van de Vossenberg, John R. B. Palmer, Frederic Bartumeus, Marc Ventura, Arjan Stroo   +13 more
doaj   +1 more source

Claroideoglomus etunicatum and Bacillus thuringiensis Affect the Growth of the Invasive Plant Ageratina adenophora and Its Defense Against the Specialist Herbivore Procecidochares utilis

Microorganisms
Exotic plants can selectively recruit beneficial microorganisms, such as arbuscular mycorrhizal fungi (AMFs) and Bacillus spp., during their invasion process to enhance growth and competitiveness by improving nutrient absorption and strengthening defense
Ewei Du, Pengcun Li, Wenyuan Zhao, Rongchao Luo, Yaping Chen, Minghong Lu, Zhongxiang Sun, Furong Gui   +7 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Comparative Analysis of Phenolic Profiles and Antioxidant Activity in the Leaves of Invasive Amelanchier × spicata (Lam.) K. Koch in Lithuania

Plants
The environmental impact of invasive species necessitates creating a strategy for managing their spread by utilising them as a source of potentially high-value raw materials. Amelanchier × spicata (Lam.) K. Koch (dwarf serviceberry) is a shrub species in
Sandra Saunoriūtė, Kristina Zymonė, Mindaugas Marksa, Lina Raudonė   +3 more
doaj   +1 more source