Results 51 to 60 of about 795,741 (279)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Floristic Composition and Changes in Alien Plant Occurrence on Anmado Island, Korea [PDF]

Geo Data
This study analyzed the occurrence patterns and changes of alien plant species on Anmado Island, located in Nagwol-myeon, Yeonggwang-gun, Jeollanam-do, based on floristic surveys conducted in 2012, 2020, and 2024.
Soo-In Lee, Hyerin Yu, Donghui Choi, A-Ram Jo   +3 more
doaj   +1 more source

Conditions for Investment in Genetic Biocontrol of Pest Vertebrates in Australia

Frontiers in Agronomy, 2022
Managing pest vertebrate species in Australia is a significant challenge for government, industry, research sectors and land-managers. Innovative tools such as genetic biocontrol offers decision-makers a potentially effective means of reducing the impact
Lucy Carter, Lucy Carter, Aditi Mankad, Aditi Mankad, Susan Campbell, Wendy Ruscoe, Wendy Ruscoe, Kevin P. Oh, Kevin P. Oh, Peter R. Brown, Peter R. Brown, Margaret Byrne, Mark Tizard, Mark Tizard, Mark Tizard, Tanja Strive, Tanja Strive   +16 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

First confirmed record of Nymphoides peltata (S.G.Gmel.) Kuntze (Menyanthaceae) naturalised in southern Africa

Bothalia: African Biodiversity & Conservation, 2018
Background: Nymphoides peltata is a hydrophyte with a nymphaeid growth form and is known to be an invader of aquatic ecosystems. Objectives: To document the presence of N. peltata outside of cultivation in southern Africa.
Michael D. Cheek
doaj   +1 more source

Five-Year Response of Spontaneous Vegetation to Removal of Invasive Amur Bush Honeysuckle Along an Urban Creek [PDF]

, 2019
Non-native invasive species have major impacts on landscapes worldwide, but their effects in urban areas are not well documented. We quantified the response of naturally regenerating vegetation along an urban creek to removal of the invasive shrub ...
Brown, Kelly H., Dolan, Rebecca W.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Antennal and abdominal transcriptomes reveal chemosensory gene families in the coconut hispine beetle, Brontispa longissima

Scientific Reports, 2017
Antennal and abdominal transcriptomes of males and females of the coconut hispine beetle Brontispa longissima were sequenced to identify and compare the expression patterns of genes involved in odorant reception and detection.
Shu-Ying Bin, Meng-Qiu Qu, Ke-Ming Li, Zheng-Qiang Peng, Zhong-Zhen Wu, Jin-Tian Lin   +5 more
doaj   +1 more source