Results 111 to 120 of about 2,239,775 (376)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
On the economical politics of invention [PDF]
Filozofija i DruštvoThis article tackles the question of invention in Jacques Derrida’s thought of deconstruction according to two perspectives. In the first part, drawing on “Psyché: Invention of the Other”, it examines its economic implications; in the second ...
De Michele Giustino
doaj +1 more source
Dynamic resource allocation scheme for distributed heterogeneous computer systems [PDF]
, 1991 This invention relates to a resource allocation in computer systems, and more particularly, to a method and associated apparatus for shortening response time and improving efficiency of a heterogeneous distributed networked computer system by ...
Liu, Howard T., Silvester, John A.
core +1 more source
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
The 'Invention' of the Natural Method of Language Teaching [PDF]
, 1920 Erwin Escher
openalex +1 more source
Whole body cleaning agent containing N-acyltaurate [PDF]
, 1992 The subject invention relates to a human cleansing agent particularly suitable for use in long duration spaceflight and to a method of bathing with the agent.
Lentsch, Steven E.
core +1 more source
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source
An Address ON THE HISTORY OF THE INVENTION AND DISCOVERY OF SPECTACLES: Being the Inaugural Address delivered before the Members of the Bradford Division of the British Medical Association [PDF]
, 1913 G. H. Oliver
openalex +1 more source
Molecular Oncology, EarlyView.Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban +12 more
wiley +1 more source