Results 51 to 60 of about 2,239,775 (376)
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Ladder polymers for use as high temperature stable resins or coatings [PDF]
, 1990 An object of the invention is to synthesize a new class of ladder and partial ladder polymers. In accordance with the invention, the new class of ladder and partial ladder polymers are synthesized by polymerizing a bis-dienophile with a bis-diene ...
Meador, Mary Ann
core +1 more source
The Invention of Creativity: Modern Society and the Culture of the New
Contemporary Sociology, 2019 caust. Cambridge, UK: Polity Press. Beilharz, Peter. 2001. ‘‘Introduction: Reading Zygmunt Bauman.’’ Pp. 1–17 in The Bauman Reader, edited by P. Beilharz. Malden, MA: Blackwell. Blackshaw, Tony. 2005. Zygmunt Bauman. New York: Routledge. Giddens, Anthony.
Allyson Stokes
semanticscholar +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
Quadrants of invention: Individual patent applications as unutilized resource of innovative capacity
International Entrepreneurship Review, 2020 Objective: This paper emphasizes the importance of isolating individual invention from organizational inventors such as private companies or universities.
Irina Ervits
doaj +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source
The Invention of Consciousness [PDF]
Topoi, 2017 In English we use the word “invention” in two ways. First, to mean a new device or process developed by experimentation, and designed to fulfill a practical goal. Second, to mean a mental fabrication, especially a falsehood, designed to please or persuade. In this paper I argue that human consciousness is an invention in both respects.
openaire +4 more sources
FEBS Letters, EarlyView.Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki +4 more
wiley +1 more source