Results 81 to 90 of about 86,889 (293)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
AgricultureThe Transforming Growth Factor-β (TGF-β) cascade plays a critical role in insect metamorphosis and involves cell-surface receptors known as type I and II, respectively (TβRI and TβRII).
Yuxing Zhang +3 more
doaj +1 more source
No Lords A-Leaping: Fanon, C.L.R. James, and the Politics of Invention
Humanities, 2014 What happens to Fanonism when, instead of resistance or liberation, it becomes a discourse of invention? What happens to Fanon’s critique of colonialism and his imagining of a decolonial future, when that critique and imagining are staked not on the ...
David Marriott
doaj +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
The 'Invention' of the Natural Method of Language Teaching [PDF]
, 1920 Erwin Escher
openalex +1 more source
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef +10 more
wiley +1 more source
Nature, 1885 IN your number for October 15 (p. 573) your numerous scientific readers will be interested to find a pretty long letter under the above heading from so able a seismologist as Prof. John Milne, of Tokio, Japan. Yet, his invitation notwithstanding, I must decline any discussion with him, either about my old letters which he refers to, or his own much ...
openaire +2 more sources
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Mandelonitrile produced by commensal bacteria protects the Colorado potato beetle against predation
Nature CommunicationsLarvae and adults of the Colorado potato beetle (Leptinotarsa decemlineata), a major pest of potato crops, display conspicuous coloration to advertise their toxicity to predators. However, the identity of the toxic compounds remains unclear.
Wei-Nan Kang +8 more
doaj +1 more source