Results 81 to 90 of about 790,747 (335)
Nature CommunicationsDihydroxyacid dehydratase (DHAD), a key enzyme in branched-chain amino acid synthesis in plants, is a promising yet unexploited herbicide target.
Bo He +15 more
doaj +1 more source
Bacon et la méthode : la libération de l’invention
Revue LISA, 2014 In this article, I examine how Bacon is able to justify his promise that the new way he proposes to follow in science is fruitful. I show that such a promise makes sense only if Bacon does not claim that he totally rejects past philosophy.
Luc Peterschmitt
doaj +1 more source
Understanding the Doctrine of Patentable Subject Matter [PDF]
, 2010 The doctrine of patentable subject matter precludes basic inventions such as abstract ideas and laws of nature from patent protection. However, current economic thinking of the patent systemstresses the necessity of rewarding pioneering inventors in ...
Chiou, Jing-Yuan
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Education and invention. [PDF]
Modern growth theory puts invention on the center stage. Inventions are created by individuals, raising the question: can we increase number of inventors? To answer this question, we study the causal effect of M.Sc.
Toivanen, Otto, Väänänen, Lotta
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Reaction cured glass and glass coatings [PDF]
, 1978 The invention relates to reaction cured glass and glass coatings prepared by reacting a compound selected from the group consisting of silicon tetraboride, silicon hexaboride, other boron silicides, boron and mixtures with a reactive glass frit composed ...
Goldstein, H. E. +2 more
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Sulfenamides as flame retardants [PDF]
, 2015 FIELD OF THE INVENTION The present invention is in the field of flame retardants and relates to use of sulfenamides as flame retardants, in particular in polymeric sub ...
Aubert, Melanie +3 more
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Phase Length Optical Phase-Locked-Loop Sensor [PDF]
The invention is a device that provides a high resolution measurement of the change in optical phase length from the device optical system source to an optical reflector.
Heyman, Joseph S.
core +1 more source