Results 81 to 90 of about 196,083 (317)
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Journal of Intellectual PropertySupreme Court decision 2017Hu1304 has established an inherency doctrine in determining novelty. According to the decision, it is not enough to simply show the possibility or probability that something can be done to show prior art to be the same as the ...
Joohwan Lee
doaj +1 more source
What Inspires Leisure Time Invention? [PDF]
This paper seeks to understand the intriguing but only sparsely explored phenomenon of “leisure time invention,” where the main underlying idea for the new product or process occurs when the inventor is away from the workplace.
Davis, Lee N. +2 more
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Nature CommunicationsDihydroxyacid dehydratase (DHAD), a key enzyme in branched-chain amino acid synthesis in plants, is a promising yet unexploited herbicide target.
Bo He +15 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Conductive film based on organic waste filler for electronic devices
, 2013 Macau International Innovation & Invention Expo 2013 (IIEX), 28th June - 30th June 2013 organized by Macao Innnovation & Invention Association at Macau Fisherman Wharf Exhibition Centre, China.This conductive film incorporation with organic waste filler ...
Supri Jalilah, Jalil, Assoc. Prof. Dr. (Supervisor) +1 more
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Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Bio-Milk Coagulant from Streblus asper
, 2013 Macau International Innovation & Invention Expo 2013 (IIEX), 28th June - 30th June 2013 organized by Macao Innnovation & Invention Association at Macau Fisherman Wharf Exhibition Centre, China.Kesinai or scientifically known as Streblus asper (Family ...
Huzairy, Hassan +4 more
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