Results 101 to 110 of about 8,047 (306)
Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis
Advanced Science, EarlyView.Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang +16 more
wiley +1 more source
A Comparative Study of DoD and Civilian Hospital Inventory Management Systems
, 1991 The purpose of this thesis was to determine if one method of inventory management would standardize procedures and minimize costs for Department of Defense and civilian hospitals.
Lemay, Karen A.
core
Advanced Science, EarlyView.Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei +15 more
wiley +1 more source
Prevalence of Depression and Anxiety in Patients with Carpal Tunnel Syndrome, Rafsanjan, Iran 2014
Journal of Mazandaran University of Medical Sciences, 2017 Background and purpose: Night time pain and paresthesia are the most common symptoms of carpal tunnel syndrome (CTS). Neuropathic pain and insomnia (due to night pain) accompanied by depression influence the quality of life, and response to treatment. So,
Amir Moghadam-Ahmadi +4 more
doaj
The drug inventories evaluation of healthcare facilities using ABC and VED analyzes
, 2018 "Always Better Control" (ABC) and "Vital Essential Desirable" (VED) are widely used methods for controlling drug inventories. The purpose of this study is to contribute to the optimal level of drug storage for the hospital by evaluating the annual ...
Yilmaz, Faruk
core +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao +7 more
wiley +1 more source
Internal financial constraints, external financial constraints, and investment choice: Evidence from a panel of UK firms [PDF]
This paper uses a panel of 24184 UK firms over the period 1993-2003 to study the extent to which the sensitivity of investment to cash flow differs at firms facing different levels of internal and external financial constraints.
Alessandra Guariglia
core
Factors affecting red blood cell storage age at the time of transfusion
, 2013 Background Clinical trials are investigating the potential benefit resulting from a reduced maximum storage interval for red blood cells (RBCs). The key drivers that determine RBC age at the time of issue vary among individual hospitals.
Dzik, WH +11 more
core +1 more source
Advanced Science, EarlyView.Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang +32 more
wiley +1 more source