Results 121 to 130 of about 93,441 (315)

Efficacy of Inebilizumab in N‐MOmentum Trial Participants With or Without Prior Immunosuppressants

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This post hoc analysis examined the impact of prior immunosuppressants on the long‐term efficacy and safety of inebilizumab, a cluster of differentiation 19+ B‐cell–depleting monoclonal antibody, in participants with aquaporin‐4–seropositive neuromyelitis optica spectrum disorder from the N‐MOmentum trial (NTC02200770).
Bruce A. C. Cree   +9 more
wiley   +1 more source

Inventories and the business cycle: an overview [PDF]

open access: yes
A review of research on the relationship between inventory investment and business cycle fluctuations, focusing on the developments of the last 15 years. A central issue in the literature, the relative importance of demand and supply shocks as sources of
Terry J. Fitzgerald
core  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Recent evidence on the muted inventory cycle [PDF]

open access: yes
Inventories play an important role in business cycles. Inventory build-ups add momentum to the economy during expansions, while inventory liquidations sap economic strength during recessions.
Andrew J. Filardo
core  

El conocimiento histórico del libro y la biblioteca novohispanos: representación de las fuentes originales The historic knowledge of new spain book and library: representation of original sources

open access: yesInformación, Cultura y Sociedad, 2007
El conocimiento del libro y las bibliotecas en la Nueva España es escaso, en comparación con el abundante recurso bibliográfico y documental del pasado colonial que se conserva en México.
Idalia García
doaj  

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe   +7 more
wiley   +1 more source

Fortalezas y debilidades de los inventarios de cementos para su empleo en análisis de ciclo de vida (ACV)

open access: yesBoletín de la Sociedad Española de Cerámica y Vidrio, 2004
Life-Cycle Assessment (LCA) has become a common and accepted tool for quantifying the environmental impact of products. It is frequently used in some industrial sectors but this is not the case for construction products like cement.
Aguado, A., Josa, A., Cardim, A.
doaj  

La surveillance des émissions anthropiques de CO2 depuis l’espace : un enjeu géopolitique émergent

open access: yesL'Espace Politique
The Paris climate agreement in 2015, and more generally policies to combat climate change, are based on knowledge of greenhouse gas emissions, in particular carbon dioxide (CO2) emissions, from human activity, established by inventories combining data on
Grégoire Broquet, Frédéric Chevallier
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito   +8 more
wiley   +1 more source

Production Planning and Inventories Optimization: A Backward Approach in the Convex Storage Cost Case. [PDF]

open access: yes
We study the deterministic optimization problem of a profit-maximizing firm which plans its sales/production schedule. The firm controls both its production and sales rates and knows the revenue associated to a given level of sales, as well as its ...
Tahraoui, Rabah   +2 more
core  

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