Results 131 to 140 of about 121,760 (314)

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova   +9 more
wiley   +1 more source

Optimise initial spare parts inventories: an analysis and improvement of an electronic decision tool. [PDF]

open access: yes
Control of spare parts is very difficult as demands can be very low (once in a few years is no exception), while the consequences of a stockout can be severe.
Dekker, R.   +3 more
core  

Emission Inventories of OCS Production and Development Activities in the Gulf of Mexico, Final Report [PDF]

open access: yes, 2003
Summary describing the work completed at Sonoma Technology, Inc. for Emission Inventories of OCS Production and Development Activities in the Gulf of Mexico.
Sonoma Technology, Inc.
core  

Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias   +3 more
wiley   +1 more source

Inventory Cycles [PDF]

open access: yes, 2008
This paper investigates a rational dynamic stochastic general equilibrium model with a stockout constraint and a production chain. Our model shows that both stockout avoidance and cost shock mechanisms replicate stylised inventory facts -- production is more volatile than sales and inventory investment is procyclical.
openaire   +2 more sources

The increasing importance of retailers' inventories [PDF]

open access: yes
Although inventory--sales (IS) ratios and inventory volatility have declined somewhat since the early 1980s, little evidence supports the view that declining IS ratios are associated with declines in inventory investment volatility. In the retail sector,
Paula R. Worthington
core  

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong   +10 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

OPTIMIZACIÓN DE LOS NIVELES DE INVENTARIO EN UNA CADENA DE SUMINISTRO / INVENTORY LEVELS OPTIMIZATION IN A SUPPLY CHAIN

open access: yesRevista Científica de Ingeniería Industrial, 2012
La gestión de inventarios es un tema muy estudiado por la Gestión de Operaciones y la Investigación de Operaciones para optimizar el costo de la gestión de los inventarios.
José Antonio Díaz-Batista   +1 more
doaj  

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