Results 141 to 150 of about 1,282 (189)

Toxicokinetic modelling of the synthetic cannabinoid 5F‐MDMB‐P7AICA and its main metabolite in pigs following pulmonary administration

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Since their emergence on the drug market, synthetic cannabinoids (SC) are still gaining increasing importance in forensic toxicology. The representatives of the so‐called new psychoactive substances have in common that they have not undergone preclinical safety studies. Hence, knowledge on toxicokinetic (TK) data is sparse.
Adrian A. Doerr   +10 more
wiley   +1 more source

Coastal evolution, environmental change and carbon storage in the Thung Prong Thong Mangrove, eastern Gulf of Thailand

open access: yesBoreas, EarlyView.
Palaeoenvironmental records along the eastern coast of Thailand remain sparse, with only a few studies attempting to reconstruct past climatic and environmental conditions. However, additional palaeoenvironmental, palaeoclimatic and sea‐level records are needed to improve our understanding of coastal evolution and local environmental changes.
Sakonvan Chawchai   +7 more
wiley   +1 more source

What controls forest litter decomposition? A coordinated distributed teabag experiment across ten mountains

open access: yesEcography, EarlyView.
Litter decomposition in mountainous forest ecosystems is an essential process that affects carbon and nutrient cycling. However, the contribution of litter decomposition to terrestrial ecosystems is difficult to estimate accurately because of the limited comparability of different studies and limited data on local microclimatic and non‐climatic factors.
Shiyu Ma   +24 more
wiley   +1 more source

The Global Dam Watch database of river barrier and reservoir information for large-scale applications. [PDF]

open access: yesSci Data
Lehner B   +23 more
europepmc   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

open access: yesThe FEBS Journal, EarlyView.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima   +12 more
wiley   +1 more source

Periphyton closes the nitrogen budget gap in rice paddies. [PDF]

open access: yesNatl Sci Rev
Sun P   +5 more
europepmc   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

open access: yesThe FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi   +8 more
wiley   +1 more source

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