Results 41 to 50 of about 565,816 (301)

Modelling and comparison of stability metrics for a re-optimisation approach of the Inventory Routing Problem under demand uncertainty

open access: yesEURO Journal on Transportation and Logistics, 2021
The inventory routing problem (IRP) is an optimisation problem that integrates transportation and inventory management decisions. When subjected to unexpected events such as demand changes, the a posteriori approach consists in re-optimising including ...
Faycal A. Touzout   +2 more
doaj   +1 more source

Green Inventory Routing Problem using Hybrid Genetic Algorithm

open access: yesJournal of Computing Research and Innovation, 2021
Carbon dioxide (CO2) is known as one of the largest sources of global warming. One of the ways to curb CO2 emissions is by considering the environmental aspect in the supply chain management.
Huda Zuhrah Ab Halim   +5 more
doaj   +3 more sources

A modified adaptive genetic algorithm for multi-product multi-period inventory routing problem

open access: yesSustainable Operations and Computers, 2022
Recent developments in urbanization and e-commerce have pushed businesses to deploy efficient systems to decrease their supply chain cost. Vendor Managed Inventory (VMI) is one of the most widely used strategies to effectively manage supply chains with ...
Meysam Mahjoob   +4 more
doaj   +1 more source

The Robust Two-Echelon Inventory Routing Problem for Vaccine Supply System – A Heuristic Method

open access: yesPromet (Zagreb)
Vaccine supply chains confront several challenges in guaranteeing security of vaccines from the phase of production to the injection. Thus, it is crucial to construct a robust vaccine supply system that helps store and deliver vaccines safely and ...
Gang CHEN   +4 more
doaj   +1 more source

Receiver-driven routing for community mesh networks [PDF]

open access: yes, 2013
Community wireless mesh networks are decentralized and cooperative structures with participation rules that define their freedom, openness and neutrality.
Navarro, Leandro   +9 more
core   +1 more source

An inventory location routing model with environmental considerations

open access: yesMATEC Web of Conferences, 2017
In this work we consider an integrated Inventory Location Routing problem ILRP. The objective is to select depots to open, the routes to perform distribution from the capacitated depots to the clients by a homogeneous fleet of vehicles and over a multi ...
Lerhlaly Sanaa   +4 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Enhanced multi-task deep reinforcement learning for the integrated inventory-routing problem under VMI mode

open access: yesManagement System Engineering
Effective inventory replenishment and routing are crucial for minimizing supply chain costs and enhancing operational efficiency. In this paper, we focus on the integrated optimization of inventory replenishment and routing problems in Vendor Managed ...
Gang Lu   +3 more
doaj   +1 more source

Inventory Routing Problem with Facility Location [PDF]

open access: yes, 2019
We study problems that integrate depot location decisions along with the inventory routing problem of serving clients from these depots over time balancing the costs of routing vehicles from the depots with the holding costs of demand delivered before they are due.
Yang Jiao, R. Ravi 0001
openaire   +2 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

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