Results 101 to 110 of about 2,605,238 (373)

Changes in Primary Care Quality Associated With Implementation of the Veterans Health Administration Preventive Health Inventory

, 2023
Chelle L. Wheat, Eric Gunnink, Jorge Rojas, Ami A. Shah, Karin M. Nelson, Edwin S. Wong, Kristen E. Gray, Susan E. Stockdale, Ann‐Marie Rosland, Evelyn T. Chang, Ashok Reddy   +10 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Evaluating Tree Species Mapping: Probability Sampling Validation of Pure and Mixed Species Classes Using Convolutional Neural Networks and Sentinel-2 Time Series

Remote Sensing
The accurate large-scale classification of tree species is crucial for the monitoring, protection, and management of the Earth’s invaluable forest ecosystems.
Tobias Schadauer, Susanne Karel, Markus Loew, Ursula Knieling, Kevin Kopecky, Christoph Bauerhansl, Ambros Berger, Stephan Graeber, Lukas Winiwarter   +8 more
doaj   +1 more source

Instability of Dynamic Inventory Systems [PDF]

We show in this paper that instability is an intrinsic cause of production variability in a dynamic inventory system. We first show that a unique stationary optimal policy exists for both full-backlog and lost-sales case and under the policy a firm ...
Jia Yan, John Liu
core  

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Linking behavioral ecology and population monitoring: The importance of group size for spatial population models

Ecosphere
Modeling the spatial distribution of wildlife abundance is paramount for management. In group‐forming species, group size and occurrence may be governed by different ecological processes.
Zackary J. Delisle, Joshua H. Schmidt, Eric J. Wald, Kyle A. Cutting, Mathew S. Sorum, Buck Mangipane, Kyle Joly, Raime B. Fronstin, Matthew D. Cameron, Bridget L. Borg   +9 more
doaj   +1 more source

Lean inventory corrections [PDF]

Inventories
Donald S. Allen
core  

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source