Results 71 to 80 of about 10,051,182 (294)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Warehouse management practices and business performance of small-scale grapes processing firms: evidence from Tanzania

open access: yesCogent Business & Management
This paper examines the relationship between warehouse management practices including material handling, storage, inventory, and packaging and the business performance of small-scale grapes processing firms in Dodoma Region, Tanzania.
Debora Chelestino Kisinga   +2 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Evidence of improved inventory control [PDF]

open access: yes
Inventory data applied to a standard partial stock-adjustment model demonstrate that inventory control, defined by desired marginal inventory-sales ratios and speeds of adjustment, improved in the last decade or so, particularly in the manufacturing ...
Dan M. Bechter, Stephen Stanley
core  

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

Metamodelling of Inventory-Control Simulations Based on a Multilayer Perceptron

open access: yesTransport and Telecommunication, 2019
Inventory control problems arise in various industries, and each single real-world inventory is replete with non-standard factors and subtleties. Practical stochastic inventory control problems are often analytically intractable, because of their ...
Jackson Ilya   +3 more
doaj   +1 more source

PENGEMBANGAN SISTEM PENDUKUNG KEPUTUSAN PENGENDALIAN PERSEDIAAN BARANG MENGGUNAKAN METODE ECONOMIC ORDER QUANTITY (EOQ) DAN MIN-MAX BERBASIS WEB (STUDI KASUS : APOTEK SAHABAT QITA)

open access: yesJurnal Nasional Pendidikan Teknik Informatika (JANAPATI), 2019
Inventory control is very important because the shortage or excess inventory is a factor that triggers an increase in cost. Excess inventory will make the cost incurred to be greater and risk of damage or expiration, whereas if a small inventory of goods
Gde Gung Prabawa   +2 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

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