Results 11 to 20 of about 54,198 (283)
Route and fleet design for cyclic inventory routing
European Journal of Operational Research, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Birger Raa, Wout Dullaert
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An Integrated Inventory-Transportation System with Periodic Pick-Ups and Leveled Replenishment [PDF]
, 2013 In this paper we develop a combined inventory-transportation system. The general idea is to integrate a simple replenishment policy with a routing component to derive operationally consistent standard routes as a basis for milk run design.
Grunewald, Martin +2 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Modeling and solving the multi-period inventory routing problem with constant demand rates [PDF]
, 2012 The inventory routing problem (IRP) is one of the challenging optimization problems in supply chain logistics. It combines inventory control and vehicle routing optimization.
Aghezzaf, El-Houssaine, Zhong, Yiqing
core +1 more source
Complexity of inventory routing problems when routing is easy [PDF]
Networks, 2019 AbstractIn the inventory routing problem (IRP) inventory management and route optimization are combined. The traveling salesman problem (TSP) is a special case of the IRP, hence the IRP is NP‐hard. We investigate how other aspects than routing influence the complexity of a variant of the IRP.
Annelieke C. Baller +3 more
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FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows
Advanced Engineering Materials, EarlyView.A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba +5 more
wiley +1 more source
Heuristic Sequence Selection for Inventory Routing Problem [PDF]
Transportation Science, 2020 In this paper, an improved sequence-based selection hyper-heuristic method for the Air Liquide inventory routing problem, the subject of the ROADEF/EURO 2016 challenge, is described. The organizers of the challenge have proposed a real-world problem of inventory routing as a difficult combinatorial optimization problem.
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Biomass Native Structure Into Functional Carbon‐Based Catalysts for Fenton‐Like Reactions
Advanced Functional Materials, EarlyView.This study indicates that eight biomasses with 2D flaky and 1D acicular structures influence surface O types, morphology, defects, N doping, sp2 C, and Co nanoparticles loading in three series of carbon, N‐doped carbon, and cobalt/graphitic carbon. This work identifies how these structural factors impact catalytic pathways, enhancing selective electron
Wenjie Tian +7 more
wiley +1 more source