Results 231 to 240 of about 52,620 (279)

A green and optimized approach for lactic acid recovery from fermented molasses using n‐butanol for local industrial applications in Côte d’Ivoire

open access: yesBiofuels, Bioproducts and Biorefining, EarlyView.
Abstract Lactic acid is a valuable organic compound with wide applications in the pharmaceutical, food, and biodegradable plastics industries. As Côte d’Ivoire seeks to strengthen its industrial capacity and promote sustainable practices, the development of efficient and environmentally benign methods for the recovery and purification of lactic acid ...
Asengo Gerardin Mabia   +7 more
wiley   +1 more source

A new inventory routing problem with route and schedule unpredictability

open access: yesApplied Mathematical Modelling
Marlize H. Visser, Jan H. van Vuuren
openaire   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg   +7 more
wiley   +1 more source

Effects of Renal and Hepatic Impairment on the Pharmacokinetics of Zilurgisertib

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim Small‐molecule activin receptor‐like kinase‐2 inhibitor zilurgisertib (INCB000928) is under investigation in a pivotal trial for the treatment of fibrodysplasia ossificans progressiva (FOP), an ultrarare genetic condition. This analysis assessed effects of renal and hepatic impairment on zilurgisertib pharmacokinetics.
Yan‐ou Yang   +5 more
wiley   +1 more source

Through the lens of marketing authorization holders: experience in use of real‐world data and real‐world evidence in drug development and regulatory submissions in EU

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The aim of this study was to assess the general and product‐specific experiences of MAHs use of RWD/RWE in medicines development and in their regulatory submissions, and to explore organizational aspects of MAHs related to RWD/RWE. Methods An electronic survey was conducted, and information collected directly from MAHs.
Sini M. Eskola   +5 more
wiley   +1 more source

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