Results 61 to 70 of about 4,063,811 (360)

Inverse polynomial optimization

, 2012
We consider the inverse optimization problem associated with the polynomial program f^*=\min \{f(x): x\in K\}$ and a given current feasible solution $y\in K$. We provide a systematic numerical scheme to compute an inverse optimal solution.
Lasserre, Jean-Bernard
core   +3 more sources

Inverse molecular design using machine learning: Generative models for matter engineering

Science, 2018
The discovery of new materials can bring enormous societal and technological progress. In this context, exploring completely the large space of potential materials is computationally intractable.
Benjamín Sánchez-Lengeling, Alán Aspuru-Guzik   +1 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Prosody and scope in German inverse linking constructions [PDF]

, 2009
In German, prosody interacts with quantifier scope. We investigate this interaction in inverse linking constructions. We present evidence from elicited production of linguistically naive speakers supporting the following two claims: 1) There are two ...
Bott, Oliver, Sauerland, Uli
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Inverse mass matrix via the method of localized lagrange multipliers [PDF]

, 2017
An efficient method for generating the mass matrix inverse is presented, which can be tailored to improve the accuracy of target frequency ranges and/or wave contents.
Cho, Sang S., Felippa, C.A., González Pérez, José Ángel, Kolman, Radek, Papadrakakis M., Fragiadakis M. (Coordinador), Park, K.C.   +5 more
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Spectral dependence of photoinduced spin precession in DyFeO3

, 2011
Spin precession was nonthermally induced by an ultrashort laser pulse in orthoferrite DyFeO3 with a pump-probe technique. Both circularly and linearly polarized pulses led to spin precessions; these phenomena are interpreted as the inverse Faraday effect
A. K. Zvezdin, A. M. Balbashov, A. V. Zalesskii, B. A. Ivanov, E. A. Turov, H. P. J. Wijn, Kazuo Kuroda, L. D. Landau, Ryugo Iida, Takuya Satoh, Tsutomu Shimura, V. G. Baryakhtar, V. V. Eremenko, Yoshinori Tokura, Yusuke Tokunaga   +14 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source