Results 41 to 50 of about 3,228,264 (291)

Identification of raloxifene as a novel CB2 inverse agonist [PDF]

open access: yesBiochemical and Biophysical Research Communications, 2013
The purpose of the current study was to apply a high throughput assay to systematically screen a library of food and drug administration (FDA)-approved drugs as potential ligands for the cannabinoid receptor 2 (CB2). A cell-based, homogenous time resolved fluorescence (HTRF) method for measuring changes in intracellular cAMP levels was validated and ...
Pritesh, Kumar, Zhao-Hui, Song
openaire   +2 more sources

Parallel Implementation of a Sensitivity Operator-Based Source Identification Algorithm for Distributed Memory Computers

open access: yesMathematics, 2022
Large-scale inverse problems that require high-performance computing arise in various fields, including regional air quality studies. The paper focuses on parallel solutions of an emission source identification problem for a 2D advection–diffusion ...
Alexey Penenko, Evgeny Rusin
doaj   +1 more source

Feedback methods for inverse simulation of dynamic models for engineering systems applications [PDF]

open access: yes, 2011
Inverse simulation is a form of inverse modelling in which computer simulation methods are used to find the time histories of input variables that, for a given model, match a set of required output responses.
David J. Murray-Smith   +1 more
core   +1 more source

Contact Mistuning Identification in Bladed Disks Using Limited Experimental Data and Data-Driven Techniques

open access: yesApplied Sciences
Contact-induced mistuning at the blade–disk interface is a major source of variability in the dynamic response of bladed disks, yet its identification remains challenging due to the intrinsic complexity of the contact phenomenon.
Umidjon Usmanov   +2 more
doaj   +1 more source

A Hybrid Strategy Enhanced Sub-Sampled Recursive Second Order Algorithm for Chemical Process Intelligent Identification

open access: yesInternational Journal of Computational Intelligence Systems, 2023
The accurate dynamic model of the chemical process is an important condition for the successful implementation of advanced control in the plant. In this paper, an efficient second order algorithm for long short-term memory (LSTM) network training is ...
Yaxin Wang, Baochang Xu
doaj   +1 more source

An inverse Stefan problem: identification of boundary value

open access: yesJournal of Computational and Applied Mathematics, 1996
A spatially one-dimensional inverse Stefan problem is considered: the moving boundary (its evolution in time) is given, the temporal evolution of the temperature at the non-moving boundary is to be determined. The standard integral equation of first kind for this problem is transformed into an equivalent convolution equation.
Ang, D.D.   +2 more
openaire   +2 more sources

Inverse load identification in vibrating nanoplates

open access: yesMathematical Methods in the Applied Sciences, 2022
In this paper, we consider the uniqueness issue for the inverse problem of load identification in a nanoplate by dynamic measurements. Working in the framework of the strain gradient linear elasticity theory, we first deduce a Kirchhoff‐Love nanoplate model, and we analyze the well‐posedness of the equilibrium problem, clarifying the correct Neumann ...
Kawano A., Morassi A., Zaera R.
openaire   +2 more sources

Inverse Calibration of Confinement and Softening in RC Beam-Column Joints for Improved DSFM Predictions

open access: yesBuildings
Standard compatibility-based truss models, including the Disturbed Stress Field Model (DSFM), often underestimate the shear strength and deformation capacity of reinforced-concrete (RC) beam-column joints.
Mehmet Ozan Yılmaz
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad   +9 more
wiley   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak   +9 more
wiley   +1 more source

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