Results 61 to 70 of about 11,893,587 (282)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

AN INVERSE METHOD FOR PARAMETRIC TIMED AUTOMATA [PDF]

International Journal of Foundations of Computer Science, 2008
We consider in this paper systems modeled by timed automata. The timing bounds involved in the action guards and location invariants of our timed automata are not constants, but parameters. Those parametric timed automata allow the modelling of various kinds of timed systems, e.g. communication protocols or asynchronous circuits.
André, Étienne, Encrenaz, Emmanuelle, Fribourg, Laurent, Chatain, Thomas   +3 more
openaire   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Application of an optimal estimation inverse method to GPS/MET bending angle observations [PDF]

, 2001
Palmer et al. [2000] describes an optimal estimation inverse method for radio occultation (RO) bending angle measurements to retrieve simultaneously temperature, humidity, and surface pressure; outlines quality control procedures for retrieved profiles ...
Palmer, P. I., Barnett, J. J.
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Analysis of Heat Transfer in a Water-Cooled Thick Plate Using Solutions of the Inverse Heat Conduction Problem

Energies
This paper presents an analysis of heat transfer in a thick-walled steel plate. During the experimental studies, one surface of the plate was heated, while the other, parallel to it, was cooled with water.
Damian Joachimiak, Magdalena Jaremkiewicz, Magda Joachimiak   +2 more
doaj   +1 more source

A Novel Hybrid Approach for Numerical Modeling of the Nucleating Flow in Laval Nozzle and Transonic Steam Turbine Blades

Energies, 2017
In the present research, considering the importance of desirable steam turbine design, improvement of numerical modeling of steam two-phase flows in convergent and divergent channels and the blades of transonic steam turbines has been targeted. The first
Edris Yousefi Rad, Mohammad Reza Mahpeykar   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source