Results 61 to 70 of about 14,778,763 (297)

Eigenvalue based inverse model of beam for structural modification and diagnostics: theoretical formulation

open access: yesLatin American Journal of Solids and Structures
In the work, the problems of the beam structural modification through coupling the additional mass or elastic support, as well as the problem of diagnostics of the beam cracks, are discussed.
Leszek Majkut
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

A Data‐Centric Approach to Quantifying the Forward and Inverse Relationship Between Laser Powder Bed Fusion Process Parameters and as‐Built Surface Roughness of IN718 Parts

open access: yesAdvanced Intelligent Systems
Laser powder bed fusion (PBF‐LB) is an additive manufacturing (AM) technology for producing complex geometry parts. However, the high cost of post‐processing coarse as‐built surfaces drives the need to control surface roughness during fabrication.
Samsul Mahmood, Bart Raeymaekers
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Inverse procedural modeling of facade layouts [PDF]

open access: yesACM Transactions on Graphics, 2014
In this paper, we address the following research problem: How can we generate a meaningful split grammar that explains a given facade layout? To evaluate if a grammar is meaningful, we propose a cost function based on the description length and minimize this cost using an approximate dynamic programming framework.
Fuzhang Wu   +4 more
openaire   +4 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Least squares fitting the three-parameter inverse Weibull density [PDF]

open access: yes, 2010
The inverse Weibull model was developed by Erto [10]. In practice, the unknown parameters of the appropriate inverse Weibull density are not known and must be estimated from a random sample.
Marušić, Miljenko   +5 more
core   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Closed-Form Continuous-Time Neural Networks for Sliding Mode Control with Neural Gravity Compensation

open access: yesRobotics
This study proposes the design of a robust controller based on a Sliding Mode Control (SMC) structure. The proposed controller, called Sliding Mode Control based on Closed-Form Continuous-Time Neural Networks with Gravity Compensation (SMC-CfC-G ...
Claudio Urrea   +2 more
doaj   +1 more source

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