Results 41 to 50 of about 5,565,025 (258)

Gonadal Dysfunction in Wolfram Syndrome: A Prospective Study

open access: yesDiagnostics
Background: Wolfram syndrome (WFS), also known as DIDMOAD, is a rare monogenic neurodegenerative disorder characterized by four key components: non-autoimmune insulin-dependent diabetes mellitus (DM), optic atrophy, sensorineural hearing loss, and ...
Gema Esteban-Bueno   +1 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Inverse Generalized Maximum Flow Problems

open access: yesMathematics, 2019
A natural extension of maximum flow problems is called the generalized maximum flow problem taking into account the gain and loss factors for arcs. This paper investigates an inverse problem corresponding to this problem. It is to increase arc capacities
Javad Tayyebi, Adrian Deaconu
doaj   +1 more source

Inverse problems of determining coefficients of time type in a degenerate parabolic equation

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2022
The paper is devoted to the study of the solvability of inverse coefficient problems for degenerate parabolic equations of the second order. We study both linear inverse problems - the problems of determining an unknown right-hand side (external ...
A.I. Kozhanov   +2 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

Inverse Problems: Methods and Applications

open access: yesTrends in Computational and Applied Mathematics, 2001
Inverse problems form the basis of all measurements to the extent that they involve the determination of the cause of a phenomenon based on observations that can be affected by undesired effects such as instrument noise and an imperfect detector response
N.J. McCormick
doaj   +1 more source

Neural networks for quantum inverse problems

open access: yesNew Journal of Physics, 2022
Quantum inverse problem (QIP) is the problem of estimating an unknown quantum system from a set of measurements, whereas the classical counterpart is the inverse problem of estimating a distribution from a set of observations. In this paper, we present a
Ningping Cao   +5 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub   +24 more
wiley   +1 more source

Exploratory Associations Between Multimodal MRI-Derived Features and Neurological Symptoms in Wolfram Syndrome: A Spanish Cohort Pilot Study

open access: yesDiagnostics
Background/Objectives: Wolfram syndrome is an ultra-rare, progressive multisystem disorder in which endocrine and sensory manifestations coexist with neurological involvement.
Gema Esteban-Bueno   +2 more
doaj   +1 more source

Phaseless Parametric Inversion for System Calibration and Obtaining Prior Information

open access: yesIEEE Access, 2019
Electromagnetic inversion systems require that the experimental data be calibrated to the computational inversion model being used. In addition, accurate prior information provided to the inversion algorithm leads to higher-quality images.
Colin Gilmore   +5 more
doaj   +1 more source

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