Results 61 to 70 of about 153,277 (261)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Scale Analysis of Wavelet Regularization Inversion and Its Improved Algorithm for Dynamic Light Scattering

open access: yesApplied Sciences, 2018
In the large inversion range, the wavelet-regularization inversion method (WRIM) is an effective method for improving the inversion accuracy of dynamic light scattering (DLS) data. However, the initial decomposition scale (IDS) of this method has a great
Yajing Wang   +5 more
doaj   +1 more source

The Combinatorics of Effective Resistances and Resistive Inverses

open access: yesInformation and Computation, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

One-dimensional constrained inversion study of TEM and application in coal goafs’ detection

open access: yesOpen Geosciences, 2020
Transient electromagnetic method (TEM) is often used in urban underground space exploration and field geological resource detection. Inversion is the most important step in data interpretation.
Yuanlei Si   +3 more
doaj   +1 more source

Chromosomal Inversions with Sex-limited Effects

open access: yesNature, 1953
Uploaded by Plazi for TaxoDros. We do not have abstracts.
openaire   +3 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Effect of data error correlations on trans-dimensional MT Bayesian inversions

open access: yesEarth, Planets and Space, 2019
Real magnetotelluric (MT) data errors are commonly correlated, but MT inversions routinely neglect such correlations without an investigation on the impact of this simplification.
Rongwen Guo   +4 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Face Inversion Disproportionately Disrupts Detection of Vertical versus Horizontal, Not Long-Range versus Short-Range, Spatial Relations

open access: yesi-Perception, 2011
Presenting a face inverted disrupts sensitivity to the spacing between the features. Recent evidence suggests that inversion disproportionately affects sensitivity to vertical over horizontal changes in eye position.
Kate Crookes, William G. Hayward
doaj   +1 more source

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