Results 71 to 80 of about 11,355,090 (252)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Localization of areas of increased vibroactivity by means of the inverse method
Archives of Acoustics, 2014 Increased possibilities of parallel acquiring data and transforming them effectively together with the improvement of calculation tools made the inverse methods more important.
Lesław STRYCZNIEWICZ
doaj
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
An adaptive multiscale algorithm for efficient extended waveform inversion
, 2017 Subsurface-offset extended full-waveform inversion (FWI) may converge to kinematically accurate velocity models without the low-frequency data accuracy required for standard data-domain FWI.
Lei Fu +3 more
core +1 more source
Progress and Challenge of Optical Remote Sensing Inversion on Soil Moisture
Renmin Zhujiang, 2021 Soil moisture is an important parameter for influencing the land surface rainfall and runoff,and a key parameter for understanding the interaction of water and energy between the earth and the atmosphere.Monitoring of this parameter is of great ...
QIN Xiangdong, PANG Zhiguo, JIANG Wei
doaj
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
f(R) Cosmology, analytical inversion method
Nuclear Physics BInflation, the rapid expansion of spacetime in the early universe, provides an elegant resolution to several fundamental cosmological problems. Among various theoretical approaches, f(R) gravity offers a minimal yet powerful extension of General ...
David Senjaya
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source