Results 61 to 70 of about 155,220 (263)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Kinetic methods for inverse problems
Kinetic & Related Models, 2019 The Ensemble Kalman Filter method can be used as an iterative numerical scheme for parameter identification or nonlinear filtering problems. We study the limit of infinitely large ensemble size and derive the corresponding mean-field limit of the ensemble method.
Herty M., Visconti G.
openaire +3 more sources
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Optimization Methods for Inverse Problems [PDF]
, 2019 Optimization plays an important role in solving many inverse problems. Indeed, the task of inversion often either involves or is fully cast as a solution of an optimization problem. In this light, the mere non-linear, non-convex, and large-scale nature of many of these inversions gives rise to some very challenging optimization problems.
Ye, Nan +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Localization of areas of increased vibroactivity by means of the inverse method
Archives of Acoustics, 2014 Increased possibilities of parallel acquiring data and transforming them effectively together with the improvement of calculation tools made the inverse methods more important.
Lesław STRYCZNIEWICZ
doaj
Progress and Challenge of Optical Remote Sensing Inversion on Soil Moisture
Renmin Zhujiang, 2021 Soil moisture is an important parameter for influencing the land surface rainfall and runoff,and a key parameter for understanding the interaction of water and energy between the earth and the atmosphere.Monitoring of this parameter is of great ...
QIN Xiangdong, PANG Zhiguo, JIANG Wei
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
f(R) Cosmology, analytical inversion method
Nuclear Physics BInflation, the rapid expansion of spacetime in the early universe, provides an elegant resolution to several fundamental cosmological problems. Among various theoretical approaches, f(R) gravity offers a minimal yet powerful extension of General ...
David Senjaya
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