Results 41 to 50 of about 155,220 (263)

Comparative Analysis of Starlight Occultation Data Processing

Atmosphere, 2023
In order to improve the inversion accuracy of stellar occultation data and to provide a reference for the selection of inversion methods with higher accuracy in the future, this study compared and analyzed the inversion effects of two different methods ...
Mingchen Sun, Qinglin Zhu, Xiang Dong, Bin Xu, Hong-Guang Wang, Xuan Cheng   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Inversion of Sound Speed Profile Controlled by Sparse Observations: Research Background, Current Status and Technical Analysis

Oceans
The sound speed profile (SSP) is a core environmental parameter for underwater acoustic detection, navigation, communication, and other applications. However, its accurate acquisition is constrained by the sparsity of observational data and the ill-posed
Haopeng Fan, Shuling Xie, Shuqiang Xue
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Distributed Fiber Optic Sensing for Fracture Geometry Inversion Using All Time Steps Data

Sensors
As an advanced real-time monitoring technique, optic fiber downhole sensing has been widely applied in monitoring fracture propagation during hydraulic fracturing.
Shaohua You, Geyitian Feng, Xiaojun Qian, Qinzhuo Liao, Zhengting Yan, Shuqi Sun, Xu Liu, Shirish Patil   +7 more
doaj   +1 more source

Seismic Waveform Inversion Using the Finite-Difference Contrast Source Inversion Method

Journal of Applied Mathematics, 2014
This paper extends the finite-difference contrast source inversion method to reconstruct the mass density for two-dimensional elastic wave inversion in the framework of the full-waveform inversion.
Bo Han, Qinglong He, Yong Chen, Yixin Dou   +3 more
doaj   +1 more source

High-Resolution Seismic Characterization of Gas Hydrate Reservoir Using Wave-Equation-Based Inversion

Energies, 2022
The high-resolution seismic characterization of gas hydrate reservoirs plays an important role in the detection and exploration of gas hydrate. The conventional AVO (amplitude variation with offset) method is based on a linearized Zoeppritz equation and ...
Jie Shao, Yibo Wang, Yanfei Wang, Hongyong Yan   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

AN INVERSE METHOD FOR PARAMETRIC TIMED AUTOMATA [PDF]

International Journal of Foundations of Computer Science, 2008
We consider in this paper systems modeled by timed automata. The timing bounds involved in the action guards and location invariants of our timed automata are not constants, but parameters. Those parametric timed automata allow the modelling of various kinds of timed systems, e.g. communication protocols or asynchronous circuits.
André, Étienne, Encrenaz, Emmanuelle, Fribourg, Laurent, Chatain, Thomas   +3 more
openaire   +1 more source