Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang +19 more
wiley +1 more source
Comparison of Anatomical and Visual Outcomes between Idiopathic and Myopic Macular Holes Using the Internal Limiting Membrane or Inverted Internal Limiting Membrane Flap Technique. [PDF]
Purpose. To compare the results of vitrectomy with those of internal limiting membrane (ILM) peeling or inverted ILM flap for treating myopic or idiopathic macular hole. Methods.
Peralta Iturburu F +3 more
europepmc +2 more sources
Inverted Internal Limiting Membrane Flap Technique for Extra Large Macular Holes
Aim: To investigate the outcome of the inverted Internal Limiting Membrane (ILM) flap technique for extra large idiopathic macular holes (MHs).Methods: A retrospective non-comparative surgical case series of seven eyes of 7 patients with MHs (base diameter of at least 1000 ?m) was conducted.
Ogugua Ndubuisi Okonkwo +2 more
openaire +2 more sources
Bionic Tactile Skins for Robotics: Fundamentals, Advances, and Future Prospects
ABSTRACT Robotic bionic tactile skins (RBTSs), as crucial components of next‐generation robotic systems, have attracted significant attention in recent years. By enabling robots to achieve human‐like tactile perception and interact effectively with their surroundings, RBTSs play an essential role in enhancing robotic intelligence.
Jiajun Wu +8 more
wiley +1 more source
Clinical and cost-effectiveness of internal limiting membrane peeling for patients with idiopathic full thickness macular hole. Protocol for a Randomised Controlled Trial : FILMS (Full-thickness macular hole and Internal Limiting Membrane peeling Study) [PDF]
Background: A full-thickness macular hole (FTMH) is a common retinal condition associated with impaired vision. Randomised controlled trials (RCTs) have demonstrated that surgery, by means of pars plana vitrectomy and post-operative intraocular tamponade
Burr Jennifer +37 more
core +2 more sources
Radar‐plot comparison of consolidation quality and flexural performance of composite laminates manufactured by six vacuum‐infusion routes, evaluated at the resin‐inlet and vacuum‐port regions. ABSTRACT Conventional vacuum‐assisted resin transfer molding (C‐VARTM) is recognized as a cost‐effective resin infusion technique for manufacturing large‐scale ...
Ilhan Kahraman +8 more
wiley +1 more source
CONVENTIONAL INTERNAL LIMITING MEMBRANE PEELING VERSUS INVERTED FLAP FOR SMALL-TO-MEDIUM IDIOPATHIC MACULAR HOLE: A Randomized Trial [PDF]
To compare conventional internal limiting membrane (ILM) peeling versus inverted flap technique in small-to-medium idiopathic macular hole. METHODS: Eyes with ≤400 μm idiopathic macular holes were randomized into the conventional ILM peeling group (25 ...
Marolo, Paola +21 more
core +1 more source
\ua9 The Author(s), under exclusive licence to The Royal College of Ophthalmologists 2024. Background: To compare conventional internal limiting membrane (ILM) peeling versus inverted flap technique in small idiopathic macular hole.
D'Alterio FM +92 more
core +7 more sources
Surgical Aspects of Recurrent Macular Holes Treatment
Despite the high level of development of modern macular surgery, recurrent macular holes remain a rather serious problem for vitreoretinal surgeons. Recurrent macular holes can be of two types: macular holes that have not closed after primary surgery ...
A. N. Samoylov +3 more
doaj +1 more source
Abstract Fetal autopsy remains essential for determining the cause of intrauterine death and for supporting clinical, genetic, and forensic evaluations. However, in cases of advanced maceration, autolysis severely compromises tissue integrity, often preventing adequate identification of anatomical structures and limiting the diagnostic and medico‐legal
Francesca Buffelli +4 more
wiley +1 more source

