Results 141 to 150 of about 4,211,479 (248)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Development of the authentication and authorization processes for the iAgree portal, a platform for patient-controlled data sharing across health systems. [PDF]

JAMIA Open
Soohoo SL, Keller MS, Chen Y, Hu D, Huang SC, Kuo TT, Leder C, Lu X, Meeker D, Morse B, Moyse H, Nagaraj G, Nguyen AT, Schilling LM, Soares A, Whooley MA, Zheng K, Ohno-Machado L.   +17 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Statins enhance trastuzumab deruxtecan efficacy: preclinical synergy in HER2-negative models and clinical benefit in HER2-positive metastatic breast cancer. [PDF]

Exp Hematol Oncol
Sahin TK, Orhan C, Ozercan IH, Muglu H, Er B, Akyildiz A, Tunbekici S, Oruc A, Aykan MB, Koylu B, Akdogan O, Onur ID, Ates O, Yazici O, Selcukbiricik F, Karadurmus N, Araz M, Erdem D, Goker E, Bilici A, Aksoy S, Guven DC.   +21 more
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

<i>CEBP</i> and <i>ZEB2</i> alterations define three distinct subtypes of B-cell acute lymphoblastic leukemia. [PDF]

Hemasphere
Kim R, Passet M, Bergugnat H, Vasseur L, Leguay T, Huguet F, Hunault M, Sexton T, Benlebna M, Renard J, Raffoux E, Pastoret C, Erb C, Chat L, Delabesse E, Gachet S, Bonmati C, Balsat M, Braun T, Bidet A, Duployez N, Graux C, Chalandon Y, Rousselot P, Chevallier P, Soulier J, Lhéritier V, Dombret H, Boissel N, Clappier E.   +29 more
europepmc   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Liquid biopsies for BRAF V600E assessment and monitoring in anaplastic thyroid carcinoma: a real-world study of a tertiary cancer center. [PDF]

Endocrine
Colombo E, Ortolan E, Cavalieri S, Tamborini E, Perrone F, Capone I, Agnelli L, Paolini B, Milione M, Calareso G, Salvetti M, Platini F, Bergamini C, Alfieri S, Resteghini C, Ottini A, Caspani F, Nuzzolese I, Bottiglieri A, Massa G, Filippini DM, Pruneri G, Licitra L, Daidone MG, Locati LD.   +24 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

On the Label: Implementation of Health Warnings on Alcohol Products in 13 European Countries. [PDF]

Drug Alcohol Rev
Kokole D, Neufeld M, Correia D, Rehm J, Pettigrew S, Paradis C, Borges CF, Fernández-Shaw AN, Pinho AP, Pereira C, Juškevičiūtė E, Savvidou E, de Veld J, Plešnar L, Mergaert L, Bermúdez LC, Sawaya M, Šelović M, Kiguolytė M, Patalong M, Senica P, Palacio PL, Mitra S, Suarez Tostado S.   +23 more
europepmc   +1 more source