Results 91 to 100 of about 205,670 (312)
Annals of Gastroenterological Surgery, EarlyView.Using machine learning‐based decision tree models, patients with perihilar cholangiocarcinoma undergoing major hepatectomy with extrahepatic bile duct resection were stratified according to the risk of posthepatectomy liver failure. Separate models were developed with and without indocyanine green data, enabling clinically interpretable preoperative ...
Yuki Homma +11 more
wiley +1 more source
Germline PTPRD mutations in Ewing sarcoma: biologic and clinical implications. [PDF]
, 2013 Ewing sarcoma occurs in children, adolescents and young adults. High STAT3 levels have been reported in approximately 50% of patients with Ewing sarcoma, and may be important in tumorigenesis.
Anderson, Peter M +9 more
core +3 more sources
When Biology Meets Medicine: A Perspective on Foundation Models
Advanced Intelligent Discovery, EarlyView.Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu +3 more
wiley +1 more source
Breast Cancer Research, 2017 Background Selinexor (KPT-330) is an oral agent that has been shown to inhibit the nuclear exporter XPO1. Given the pressing need for novel therapies for triple-negative breast cancer (TNBC), we sought to determine the antitumor effects of selinexor in ...
Natalia Paez Arango +12 more
doaj +1 more source
Investigating mathematical investigations
, 1998 There are good reasons why we may involve the students in doing mathematics investigations. Recent curricula encourage this sort of activity but we notice that its application in the classroom is not a simple matter. We discuss the issues that arise when students are presented with investigative tasks, with special interest in the dynamics of the ...
Ponte, João Pedro da +4 more
openaire +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Introduction Temperature‐controlled radiofrequency (TCRF), septoplasty (ST) with turbinate reduction, and functional rhinoplasty (FR) are treatment options for nasal airway obstruction (NAO) and nasal valve dysfunction (NVD), but no direct comparison of these procedures has been performed. Methods This prospective, open‐label, non‐inferiority (
Greg Davis +13 more
wiley +1 more source
npj Precision OncologyImmunotherapy has substantially changed the landscape of cancer. We present five patients with advanced cancer who had failed standard-of-care therapies, participated in clinical trials with anti-CTLA4/anti-PD1 therapy, and had prolonged progression-free
Camila B. Xavier +2 more
doaj +1 more source
Experiences with HPTN 067/ADAPT Study-Provided Open-Label PrEP Among Women in Cape Town: Facilitators and Barriers Within a Mutuality Framework. [PDF]
, 2017 Placebo-controlled trials of pre-exposure prophylaxis (PrEP) have reported challenges with study-product uptake and use, with the greatest challenges reported in studies with young women in sub-Saharan Africa.
Amico, K Rivet +8 more
core +2 more sources
Animal Models and Experimental Medicine, EarlyView.This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin +2 more
wiley +1 more source