Results 91 to 100 of about 11,584 (267)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
ORDER OF INITIATION OF LEGAL PROCEEDINGS AND THE ANALYSIS OF INVESTIGATIVE SITUATIONS OF THE INITIAL STAGE OF INVESTIGATION OF THE CRIMES CONNECTED WITH THE DRUG TRAFFICKING [PDF]
Krymskij Naučnyj Vestnik, 2015 In article the order of initiation of criminal cases about the crimes connected with a drug trafficking is considered. Theoretical and practical questions of formation of typical investigative situations of an initial stage of investigation of crimes of ...
Alina Anapolskaya
doaj
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Theory of investigative action by S. A. Shafer (on the occasion of the Teacher’s anniversary)
Юридический вестник Самарского университетаThe issue of the concept of investigative action, which has been in the center of attention of Russian processualists for many decades, has been studied «inside and out» by both masters of Russian science and many of their followers, and to this day ...
V. A. Lazareva
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
AN INVESTIGATION OF THE DEPRESSOR ACTION OF PITUITARY EXTRACTS
Archives of Internal Medicine, 1911 I. INTRODUCTION It is generally conceded that intravenous injections of the extract of the infundibular portion of the pituitary gland cause a rise in blood-pressure ; that this rise is due to a peripheral constriction of blood-vessels, and that when repeated injections are made, the rise in pressure diminishes with each injection until a fall in ...
openaire +2 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Архів кримінології та судових наукSpecific expertise which procedural form is engagement of a specialist in investigative (search) actions is crucial in solving the majority of tactical tasks. Given that the indicated issue in the context of criminal offenses related to domestic violence
Anhelina Salnikova
doaj +1 more source