Results 151 to 160 of about 19,007,438 (352)

On the identity of Scythris tributella (Zeller, 1847) and raising Scythris terrenella (Zeller, 1847), sp. rev. from synonymy (Lepidoptera: Scythrididae)

SHILAP
A review of the Scythris tributella (Zeller, 1847) complex is given. All synonyms are reconsidered by study of the genitalia of the types and relevant specimens. One of the synonyms, S.
Bengt Å. Bengtsson
doaj   +1 more source

PANEL DISCUSSION: THE EXPANDING PROSECUTORIAL ROLE FROM TRIAL COUNSEL TO INVESTIGATOR AND ADMINISTRATOR [PDF]

, 1999
MODERATOR: Daniel C. Richman PANELISTS: Laurie L. Levenson, GerardE. Lynch, Honorable John S. Martin, Jr., Julie R.

core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Investigating error in criminal proceedings

Хабаршы. Заң сериясы, 2016
In this paper, the author discussed some issues of improving the investigative practices, improve the quality of investigation of criminal cases, the rule of law in the activities of criminal prosecution and respect for the principles of the ...
Syrlybayev M.
doaj  

Implementation of investigator-led drug clinical trial recruitment

Zhongguo linchuang yanjiu
Objective Taking the implementation of recruitment for a drug clinical trial as an example, to discuss the implementation method of investigator-led recruitment for drug clinical trials from the perspective of the investigator’s organization, with a view
SONG Xia, KAN Tingting, ZHU Ling, CHEN Peiling, ZHANG Haitao
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Overall Survival in Patients With Advanced Melanoma Who Received Nivolumab Versus Investigator's Choice Chemotherapy in CheckMate 037: A Randomized, Controlled, Open-Label Phase III Trial.

Journal of Clinical Oncology, 2017
J. Larkin, D. Minor, S. D’Angelo, B. Neyns, M. Smylie, W. Miller, R. Gutzmer, G. Linette, B. Chmielowski, C. Lao, P. Lorigan, K. Grossmann, J. Hassel, M. Sznol, A. Daud, J. Sosman, N. Khushalani, D. Schadendorf, C. Hoeller, D. Walker, G. Kong, C. Horak, J. Weber   +22 more
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source