Results 151 to 160 of about 1,273,562 (309)

Residual acceleration data on IML-1: Development of a data reduction and dissemination plan [PDF]

The research performed consisted of three stages: (1) identification of sensitive IML-1 experiments and sensitivity ranges by order of magnitude estimates, numerical modeling, and investigator input; (2) research and development towards reduction ...
Alexander, J. Iwan D., Rogers, Melissa J. B.   +1 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Persistent loss of animal diversity on a rocky shore over nine decades and across multiple investigators. [PDF]

PeerJ
Elahi R, Micheli F, Watanabe JM.
europepmc   +1 more source

The Criminal Investigator [PDF]

, 2009
Goldsworthy, Terrence
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The ARTIST Post-Market Study: Evaluating a High G' Hyaluronic Acid (HA) Injectable for Chin Combined With Midface HA Filler Treatments. [PDF]

J Cosmet Dermatol
Nikolis A, Rivers JK, Rosen N, Weinberg F, Prygova I, Bromée T.   +5 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Non-invasive vessel fractional flow reserve versus fractional flow reserve guidance to revascularize intermediate coronary stenosis (LIPSIA-STRATEGY) trial: study protocol for a randomized controlled trial. [PDF]

Trials
Majunke N, Desch S, Kister T, Buske M, Pöss J, Feistritzer HJ, Erbs S, Hösler N, Wolff J, Schneider S, Ouarrak T, Woitek F, Lenk K, Nef H, Dörr O, Sossalla S, Achenbach S, Marwan M, Barlagiannis D, Haude M, Mahabadi AA, Rassaf T, Thiele H.   +22 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Colchicine and dialysis patients (CAD): protocol for a feasibility study. [PDF]

BMJ Open
Wong YTD, Hughes LD, Norton S, Robson MG.   +3 more
europepmc   +1 more source