Results 151 to 160 of about 18,913,418 (345)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Investigating mathematical investigations
, 1998 There are good reasons why we may involve the students in doing mathematics investigations. Recent curricula encourage this sort of activity but we notice that its application in the classroom is not a simple matter. We discuss the issues that arise when students are presented with investigative tasks, with special interest in the dynamics of the ...
Ponte, João Pedro da +4 more
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Historical Test of the Tiebout Hypothesis: Local Heterogeneity from 1850 to 1990 [PDF]
The Tiebout hypothesis, which states that individuals will costlessly sort themselves across local communities according to their public good preferences, is the workhorse of the local public finance literature.
Koleman S. Strumpf, Paul W. Rhode
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Interactive Investigator, available through Virtual Museum Canada, is a website "for anyone with an interest in the different scientific methods used to solve crimes." Users will find a database of forensic science, containing short but ...
core
Известия высших учебных заведений. Поволжский регион: Общественные наукиBackground. Liability for falsification of evidence in a criminal case and the results of operational-search activities is provided for in Parts 2–4 of Article 303 of the Criminal Code of the Russian Federation.
A.V. Yashin
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source