Results 11 to 20 of about 19,007,438 (352)

Safety and efficacy of rituximab in systemic sclerosis (DESIRES): a double-blind, investigator-initiated, randomised, placebo-controlled trial.

open access: yesThe Lancet Rheumatology, 2021
BACKGROUND Systemic sclerosis is a connective tissue disease characterised by multiorgan fibrosis with an autoimmune background and poor prognosis. Although a few drugs have shown some efficacy in treating the disease, there remains a great unmet medical
S. Ebata   +14 more
semanticscholar   +1 more source

Validation of the Hidradenitis Suppurativa Investigator Global Assessment

open access: yesJAMA dermatology, 2023
Key Points Question Is the Hidradenitis Suppurativa Investigator Global Assessment (HS-IGA) a valid end-point measure for clinical trials in patients with hidradenitis suppurativa (HS?) Findings In this secondary analysis of the UCB phase 2 randomized ...
A. Garg   +10 more
semanticscholar   +1 more source

Acalabrutinib Versus Investigator’s Choice in Relapsed/Refractory Chronic Lymphocytic Leukemia: Final ASCEND Trial Results

open access: yesHemaSphere, 2022
Acalabrutinib is a Bruton tyrosine kinase inhibitor approved for patients with chronic lymphocytic leukemia (CLL). ASCEND is the pivotal phase 3 study of acalabrutinib versus investigator’s choice of idelalisib plus rituximab (IdR) or bendamustine plus ...
P. Ghia   +17 more
semanticscholar   +1 more source

The Validated Investigator Global Assessment for Atopic Dermatitis (vIGA‐AD™): a clinical outcome measure for the severity of atopic dermatitis

open access: yesBritish Journal of Dermatology, 2022
The validated Investigator Global Assessment for Atopic Dermatitis (vIGA‐AD™) is a standardized severity assessment for use in clinical trials and registries for atopic dermatitis (AD).
E. Simpson   +11 more
semanticscholar   +1 more source

Comparative Reductions in Investigator-Reported and Adjudicated Ischemic Events in REDUCE-IT.

open access: yesJournal of the American College of Cardiology, 2021
BACKGROUND REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl-Intervention Trial) randomized statin-treated patients with elevated triglycerides to icosapent ethyl (IPE) or placebo. There was a significant reduction in adjudicated events,
P. Gaba   +16 more
semanticscholar   +1 more source

The Physician-Investigator Workforce: Looking Ahead.

open access: yesAcademic medicine : journal of the Association of American Medical Colleges, 2021
Support of the U.S. health professions investigator workforce is critically important to the continued advancement of health care nationally. Physician-investigators comprise one segment of this health professions investigator workforce, which also ...
D. Andriole, R. Wolfson
semanticscholar   +1 more source

Nivolumab vs investigator's choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression.

open access: yesOral Oncology, 2018
OBJECTIVES We report 2-year results from CheckMate 141 to establish the long-term efficacy and safety profile of nivolumab and outcomes by tumor PD-L1 expression in patients with recurrent or metastatic (R/M),platinum-refractory squamous cell carcinoma ...
R. Ferris   +24 more
semanticscholar   +1 more source

«OTHER» PERSONS AS PARTICIPANTS IN SECRET INVESTIGATORS (DETECTIVE) ACTIONS (CRIMINAL CONTROL)

open access: yesНауково-інформаційний вісник Івано-Франківського університету права імені Короля Данила Галицького, 2023
Purpose. The purpose of the work is to study the current legislation that ensures the legality of secret investigative (search) actions. The author of this work substantiates the illegality of using the materials of secret investigative (search) actions ...
Lototskyi Mykhailo
doaj   +1 more source

Conducting Clinical Research During the COVID-19 Pandemic: Investigator and Participant Perspectives

open access: yesJMIR Public Health and Surveillance, 2020
As the medical landscape changes daily with the coronavirus disease (COVID-19) pandemic, clinical researchers are caught off-guard and are forced to make decisions on research visits in their ongoing clinical trials.
Prasad R. Padala, A. Jendro, K. Padala
semanticscholar   +1 more source

Treatment expectations but not preference affect outcome in a trial of CBT and exercise for pain [PDF]

open access: yes, 2017
The following are members of the MUSICIAN study team: Gary Macfarlane (Principal Investigator), John McBeth (Investigator), Deborah Symmons (Investigator), Karina Lovell (investigator), Philip Keeley (Investigator), Phil Hannaford (Investigator), Chrysa ...
Beasley, Marcus John   +3 more
core   +1 more source

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