Results 231 to 240 of about 19,007,438 (352)

Neurosurgical leadership in neuro-oncology clinical trials: A nationwide study. [PDF]

Neurosurg Rev
Ramsoomair CK, Daftari M, Desai A, Alvarez V, Himic V, Berckemeyer MA, Shlobin NA, Khalafallah AM, Wang S, Elder B, Dunn GP, Smith TR, Ivan ME, Komotar RJ, Shah AH.   +14 more
europepmc   +1 more source

Investigator-Initiated IBD Trials in the United States: Facts, Obstacles, and Answers

Inflammatory Bowel Diseases, 2017
H. Herfarth, Susan A. Jackson, B. Schliebe, Christopher Martin, A. Ivanova, Kristen Anton, R. Sandler, M. Long, K. Isaacs, M. Osterman, B. Sands, P. Higgins, J. Lewis   +12 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

SGL-TX-MR-study protocol acute effects of SGLT2 inhibitor on kidney allograft oxygen tension, a randomized, double-blind, placebo controlled crossover trial. [PDF]

Trials
Lange LB, Bistrup C.
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Type 1 diabetes screening: reframing the debate from paternalism to partnership. Reply to Scaramuzza AE, Iafusco D, Cherubini V [letter] Type 1 diabetes screening: building a clinician-patient partnership for early care of chronic beta cell failure. Reply to Mallone R, Bandini A [letter]. [PDF]

Diabetologia
Gitelman SE, Simmons K, Sherr JL, Quattrin T, Russell WE, Sunil B, Willi SM, Knecht LA, Niemoeller E, Licaj I, Miller D, DiMeglio LA.   +11 more
europepmc   +1 more source

Additional Investigations [PDF]

Deutsches Ärzteblatt international, 2016
openaire   +2 more sources

Digital Humanities and Computer-Mediated Instruction in Slavic Studies [PDF]

, 2011
Danylenko, Principal Investigator, Andriy, Frank, Co-Investigator, Ronald   +1 more
core   +1 more source

The Daunting Career of the Physician-Investigator.

Academic medicine : journal of the Association of American Medical Colleges, 2017
Ross E McKinney
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source