Results 231 to 240 of about 18,913,418 (345)

Efficacy and safety of trastuzumab deruxtecan in patients with HER2-expressing biliary tract or pancreatic tumors: a subgroup analysis of DESTINY-PanTumor02. [PDF]

ESMO Open
Oh DY, Ługowska I, Stroyakovskiy D, Jung KH, Dumas O, Penkov K, Dechaphunkul A, Oaknin A, Kim ST, Starling N, Chewaskulyong B, Charonpongsuntorn C, Doroshow D, Hsiao SY, Hung YP, Jung L, Kuptsova-Clarkson N, Michelini F, Puvvada S, Meric-Bernstam F.   +19 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

An App for Care Partners of Persons Living With Dementia (Aliviado Caregiving): Human-Centered Design Study. [PDF]

JMIR Form Res
Fernandez Cajavilca M, Lin SY, Durga A, Perez-Greenemeier S, Cheng Hom K, Lawson D, Brody A.   +6 more
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Phase III AIRTIVITY study design: verducatib (BI 1291583) in people with bronchiectasis. [PDF]

ERJ Open Res
Chalmers JD, Shteinberg M, Chotirmall SH, Sauter W, Flume PA, Jain R, Morimoto K, O'Donnell AE, Ringshausen FC, Watz H, Xu JF, Rauch J, Eleftheraki A, Engel AT, Chang AB, Nielsen KG, Benitez G, Gupta A, Mall MA, McShane PJ.   +19 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Zolbetuximab plus pembrolizumab and chemotherapy in CLDN18.2-positive, HER2-negative, PD-L1-positive gastric or gastroesophageal junction adenocarcinoma: randomized, double-blind, phase III LUCERNA trial. [PDF]

ESMO Gastrointest Oncol
Shitara K, Enzinger P, Lordick F, Smyth E, Rha SY, Van Cutsem E, Xu RH, Strickler JH, Lee P, Klempner SJ.   +9 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Beyond Infrastructure: Shared Resources as Drivers of Impact and Collaboration in the NCI Cancer Center Community. [PDF]

J Biomol Tech
Springer BC, Ambulos NP, Gosky DM.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source