Results 271 to 280 of about 19,007,438 (352)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

SHIELD study: a multicenter, open-label, single-arm trial to evaluate the safety, pharmacokinetics and antiviral activity of fostemsavir in combination with optimized background therapy (OBT) in children and adolescents with HIV who are failing their current combination antiretroviral therapy (cART) and have dual- or triple-class antiretroviral (ARV) resistance. [PDF]

BMC Infect Dis
Grasa C, Salvadori N, Nardone A, Than-In-At K, Koblansky A, Parry C, Thakkar N, Wang M, Giaquinto C, Rojo P, Cressey TR.   +10 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Assessment of the information quality of chatbot technologies on orthodontic miniscrews. [PDF]

Dental Press J Orthod
Yamaç BB, Akçar R, Şarkan İE, Arslan C.   +3 more
europepmc   +1 more source

Bridging the Regulatory Chasm in Investigator-Initiated Human Subject Cannabis Research. [PDF]

Clin Pharmacol Ther
Barkholtz HM, Naviaux W.
europepmc   +1 more source

Multilingual Video Education for Hospitalized Patients With Myocardial Infarction (EDUCATE-MI): Single-Arm Implementation Study. [PDF]

JMIR Cardio
Zeng A, O'Hagan E, Kim SK, Marschner S, Sarkies M, Wassif M, Ji M, Ayre J, McIntyre D, Chow CK, Thiagalingam A, Laranjo L.   +11 more
europepmc   +1 more source

Surrogate endpoints for survival in KEYNOTE-585: neoadjuvant/adjuvant pembrolizumab plus chemotherapy versus placebo plus chemotherapy for gastric or gastroesophageal junction adenocarcinoma. [PDF]

ESMO Open
Shitara K, Bang YJ, Wyrwicz LS, Rha SY, Oshima T, Pietrantonio F, Park YK, Lonardi S, Yañez P, Yen CJ, Metges JP, Garrido M, Moehler M, Pelles-Avraham S, Yong WP, Spallanzani A, Jensen E, Krishnan R, Shih CS, Al-Batran SE.   +19 more
europepmc   +1 more source

Soft-tissue quadriceps tendon autograft during primary anterior cruciate ligament reconstruction in Skeletally-immature patients vs. Hamstrings: A protocol for a multi-centre randomized controlled trial. [PDF]

J Orthop Surg Res
Ayeni OR, SQuASH Investigators.
europepmc   +1 more source

Effectiveness and Safety of Belotero Intense ± Lidocaine for the Correction of Nasolabial Folds, Marionette Lines, and Lip Volume Enhancement: A Randomized Post-Market Clinical Follow-Up Study. [PDF]

Aesthet Surg J Open Forum
Gerber PA, da Mota R, Gauglitz G, Greiner-Krüger D, Sebastian M, Prager W, Kravtsov M, Carreon C, Tseng Y, Sattler S.   +9 more
europepmc   +1 more source