Results 41 to 50 of about 1,467,737 (309)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Risk Analysis in Investment Appraisal [PDF]
This paper was prepared for the purpose of presenting the methodology and uses of the Monte Carlo simulation technique as applied in the evaluation of investment projects to analyse and assess risk.
Savvakis C. Savvides
core +3 more sources
Tạp chí Phát triển và Hội nhập, 2023 The objective of this research is to analyze the effectiveness of the investment project for resettlement and housing for workers in the Tra Noc Industrial Zone, Can Tho City.
Cuong Ngoc Luu, Tan Minh Nguyen
doaj +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Analysis of current investment projects and their economic justification
Економічний форумThe purpose of this study was to analyse existing investment projects in Albania and assess their economic feasibility to determine their impact on the country’s economic growth and development. The study examined 30 major investment projects in key sectors such as energy, infrastructure, and tourism. The study showed that the main investors in Albania
Shahini, Elti, Shahini, Ermir
openaire +2 more sources
Arthritis Care &Research, EarlyView.Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge +6 more
wiley +1 more source
The essence of economic evaluation of investment projects
Путеводитель предпринимателя, 2020 This article describes the key indicators for measuring the effectiveness of the investment project: payback and return, net present value, profitability index, payback period and internal rate of return.
doaj
Improvement of the cost-benefit analysis algorithm for high-rise construction projects
E3S Web of Conferences, 2018 The specific nature of high-rise investment projects entailing long-term construction, high risks, etc. implies a need to improve the standard algorithm of cost-benefit analysis. An improved algorithm is described in the article.
Gafurov Andrey +2 more
doaj +1 more source
Arthritis Care &Research, EarlyView.People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley +1 more source