Results 121 to 130 of about 783 (197)

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Adding Realism to Theories of Taxpayer Compliance

Southern Economic Journal, EarlyView.
ABSTRACT Explaining why people pay taxes has not been a central focus in the many important contributions of Jim Cox. Even so, I argue here that his work has greatly affected the way that we think about taxpayer compliance, by adding both directly and indirectly much needed realism to the theories and the applications of compliance. These contributions
James Alm
wiley   +1 more source

Professionalising the Cybersystemic Practitioner: Five Decades of STiP Education at the Open University (1971–2025)

Systems Research and Behavioral Science, EarlyView.
ABSTRACT This paper draws on over five decades of experience in educating and developing systems thinking practitioners at the Open University (OU) UK to explore the opportunities and challenges in the professionalisation of systems thinking in practice (STiP).
Ray Ison
wiley   +1 more source

Chemical Recycling as a Tool for Enabling a Second Life for Polyesters

SusMat, EarlyView.
This review presents the elucidation of the life cycle of main polyesters, detailing end‐of‐life methods, with focus of solvolysis technologies, then an analysis of LCA and TEA on literature data, an original data analytic, and, finally, a current industrial mapping of the main processes with a critical perspective on the plastic life‐cycle ecosystem ...
Nícolas Soares Urruth, Cristian de Oliveira Romera, Caio Gomide Otoni, Bruno Francisco Oechsler, Pedro Henrique Hermes de Araújo, Claudia Sayer   +5 more
wiley   +1 more source

Assessment of a Model‐Based Approach to Achieve Authorization to Operate

Systems Engineering, EarlyView.
ABSTRACT Accreditation of United States Government (USG) Information Systems (IS) is required to assure their function and security before delivery to the operational environment. However, in many cases, the baseline document‐based accreditation processes are sources of cost and schedule overruns.
Edan C. Sanchez, John M. “Mike” Borky, Thomas H. Bradley   +2 more
wiley   +1 more source

Alignment of Agile and Modular Open Systems Approach (MOSA) Principles in Systems Engineering

Systems Engineering, EarlyView.
ABSTRACT Organizations have consistently sought faster and more efficient methods for producing and delivering products. Agile principles offer essential guidance for shaping their policies and practices. The Agile Manifesto (AM) outlines 12 core principles for guiding software development but can also be applied in other contexts.
Terry Plonsky, Daniel R. Herber
wiley   +1 more source

Architecting and Industrializing Advanced Production and Manufacturing Systems for Critical Industries

Systems Engineering, EarlyView.
ABSTRACT Advanced production systems play a vital role in modern society. Such systems are developed and industrialized over multiple years and at great expense. The complexities of these systems are exacerbated in the case of metal additive manufacturing, which involves numerous process variables and relies on various auxiliary systems.
Duncan W. Gibbons, Andre F. van der Merwe   +1 more
wiley   +1 more source

Accelerating Mission Engineering: Evidence of a Stratified Landscape and a Path Toward Unified Practice

Systems Engineering, EarlyView.
ABSTRACT Mission Engineering is maturing as a Systems Engineering discipline, yet adoption of its common frameworks remains stratified. This study examines whether selective adoption is observable across ME scholarship and develops a framework to address identified barriers.
James Moreland, Nathaniel Ambler, Casey LaMar, Maegen Nix, Craig Sawyer   +4 more
wiley   +1 more source

Investigating SME‐Inclusive Public‐Private AI Innovation Network: Evidence From U.S. Small Business Administration (1991–2023)

Thunderbird International Business Review, EarlyView.
ABSTRACT Understanding innovation policy is pivotal to enhancing national competitiveness for global value chain. This research investigates an SME‐Inclusive public‐private AI innovation network over time in the U.S. context (1991–2023), revealing how a government's demand‐based innovation policy bolsters technological prowess through isomorphism and ...
Jiyoon An
wiley   +1 more source

How National Security Drives the Coevolution of International Relations and International Business Policy: Evidence From the Belt and Road Initiative

Thunderbird International Business Review, EarlyView.
ABSTRACT Focusing on the Belt and Road Initiative (BRI), this study investigates how national security drives the coevolution of China's political risk management support for multinationals and competing countries' reactions. A competing country is a nation‐state that is neither the home nor host country of a multinational but perceives the ...
Shuang Li, Xueli Huang, Fuming Jiang
wiley   +1 more source