Results 41 to 50 of about 28,053 (245)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Invariants de Witt des involutions de bas degré en caractéristique 2

Comptes Rendus. Mathématique
A $3$-fold and a $5$-fold quadratic Pfister forms are canonically associated to every symplectic involution on a central simple algebra of degree $8$ over a field of characteristic $2$.
Tignol, Jean-Pierre
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Structural changes in the thymus in the anabolic phase after exposure to experimental hyperthermia

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015
In the anabolic phase of postoperational period, restoration of the structure of the blood-thymic thymus barrier, reduced edema of perivascular and interstitial spaces in in the thymus barrier, and emergence of a large number of epithelial cells with ...
D. V. Vasendin, S. V. Michurina, I. Yu. Ishchenko   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Status of breast cancer detection in young women and potential of liquid biopsy

Frontiers in Oncology
Young onset breast cancer (YOBC) is an increasing demographic with unique biology, limited screening, and poor outcomes. Further, women with postpartum breast cancers (PPBCs), cancers occurring up to 10 years after childbirth, have worse outcomes than ...
Maya Stibbards-Lyle, Maya Stibbards-Lyle, Julia Malinovska, Julia Malinovska, Seleem Badawy, Seleem Badawy, Pepper Schedin, Kristina D. Rinker, Kristina D. Rinker, Kristina D. Rinker, Kristina D. Rinker   +10 more
doaj   +1 more source

Lactation opposes pappalysin‐1‐driven pregnancy‐associated breast cancer

EMBO Molecular Medicine, 2016
Pregnancy is associated with a transient increase in risk for breast cancer. However, the mechanism underlying pregnancy‐associated breast cancer (PABC) is poorly understood.
Yukie Takabatake, Claus Oxvig, Chandandeep Nagi, Kerin Adelson, Shabnam Jaffer, Hank Schmidt, Patricia J Keely, Kevin W Eliceiri, John Mandeli, Doris Germain   +9 more
doaj   +1 more source

Primary Mammary Organoid Model of Lactation and Involution

Frontiers in Cell and Developmental Biology, 2020
Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in ...
Jakub Sumbal, Jakub Sumbal, Aurelie Chiche, Elsa Charifou, Zuzana Koledova, Han Li   +5 more
doaj   +1 more source