Results 31 to 40 of about 10,230 (219)

Palladium(II)/Cationic 2,2’-Bipyridyl System as a Highly Efficient and Reusable Catalyst for the Mizoroki-Heck Reaction in Water

Molecules, 2010
A water-soluble and air-stable Pd(NH3)2Cl2/cationic 2,2’-bipyridyl system was found to be a highly-efficient and reusable catalyst for the coupling of aryl iodides and alkenes in neat water using Bu3N as a base.
Fu-Yu Tsai, Jun-Rong Chen, Shao-Hsien Huang   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Rhodium-catalyzed reductive carbonylation of aryl iodides to arylaldehydes with syngas

Beilstein Journal of Organic Chemistry, 2020
The reductive carbonylation of aryl iodides to aryl aldehydes possesses broad application prospects. We present an efficient and facile Rh-based catalytic system composed of the commercially available Rh salt RhCl3·3H2O, PPh3 as phosphine ligand, and ...
Zhenghui Liu, Peng Wang, Zhenzhong Yan, Suqing Chen, Dongkun Yu, Xinhui Zhao, Tiancheng Mu   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

LANTHANIDE OXYIODIDES

Тонкие химические технологии, 2016
The present review is devoted to consideration and generalization of a number of synthetic methods for lanthanide oxoiodides preparation as well as to consideration of their structural particularities and thermal stability.
N. S. Rukk, R. M. Zakalyukin, A. Yu. Skryabina   +2 more
doaj   +1 more source

Nickel-catalyzed alkyl-arylation of 3,3,3-trifluoropropene

Communications Chemistry, 2022
3,3,3-Trifluoropropene is a cost-efficient precursor for the preparation of trifluoromethylated compounds, but limited methods for its efficient transformation have been reported.
Chang Xu, Ming-Kuan Wang, Shu Zhang, Xingang Zhang   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Application of Diaminium Iodides in Binary Ionic Liquid Electrolytes for Dye-Sensitized Solar Cells

International Journal of Photoenergy, 2011
N-(2-hydroxyethyl)ethylenediaminium iodides (HEEDAIs) and N-(2-hydroxyethyl)piperazinium iodides (HEPIs) were synthesized, and their thermal properties were analysed.
Yanzhen Yang, Renjie Sun, Chengwu Shi, Yucheng Wu, Mei Xia   +4 more
doaj   +1 more source

Expanding chemical space by para-C−H arylation of arenes

Nature Communications, 2022
Biaryls are privileged structural motif used in the discovery and design of therapeutics with high affinity and specificity for a broad range of protein targets.
Sudip Maiti, Yingzi Li, Sheuli Sasmal, Srimanta Guin, Trisha Bhattacharya, Goutam Kumar Lahiri, Robert S. Paton, Debabrata Maiti   +7 more
doaj   +1 more source