Results 201 to 210 of about 76,416 (345)

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Accepted Article.
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

Editorial: Consequences of Iodine Deficiency in Pregnancy. [PDF]

Front Endocrinol (Lausanne), 2021
Lee SY.
europepmc   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Accepted Article.
This review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to transform structurally complex molecular scaffolds. By examining the scope, efficiency, and mechanistic aspects of these approaches, the review highlights protocols ...
Johanna Templ, Lars Borchardt
wiley   +1 more source

Results of the national biomonitoring program show persistent iodine deficiency in Israel. [PDF]

Isr J Health Policy Res, 2022
Barnett-Itzhaki Z, Ehrlich D, Troen AM, Rorman E, Groismann L, Blaychfeld-Magnazi M, Endevelt R, Berman T.   +7 more
europepmc   +1 more source

Highly Enantioselective Organocatalysis with Bidentate Halogen Bond Donors

Angewandte Chemie International Edition, EarlyView.
In a model Mukaiyama aldol reaction with unbiased substrates, high enantioselectivity was achieved with a modifiable bidentate iodine(I)‐based halogen bonding organocatalyst. The crucial role of halogen bonding was confirmed by the low performance of the corresponding hydrogen bond donor and via DFT calculations.
Julian Wolf, Meghana Poliyodath Mohanan, Raphaël Robidas, Revannath L. Sutar, Elric Engelage, Claude Y. Legault, Stefan M. Huber   +6 more
wiley   +1 more source

The state of iodine deficiency in Kyrgyzstan: Insights from studies of knowledge, attitudes and practices. [PDF]

PLoS One
Chyngyshpaeva Y, Dzhaliev Z, Derbishalieva Z, Ibrahim M, Lucero-Prisno DEI, Dzhusupov K.   +5 more
europepmc   +1 more source

Iodine deficiency is associated with increased thyroid hormone sensitivity in individuals with elevated TSH. [PDF]

Eur Thyroid J, 2022
Sun Y, Teng D, Zhao L, Shi X, Li Y, Shan Z, Teng W.   +6 more
europepmc   +1 more source

Is There an Ideal Diet to Protect against Iodine Deficiency? [PDF]

Nutrients, 2021
Krela-Kaźmierczak I, Czarnywojtek A, Skoracka K, Rychter AM, Ratajczak AE, Szymczak-Tomczak A, Ruchała M, Dobrowolska A.   +7 more
europepmc   +1 more source

An Atomically Dispersed Photocatalyst for Undirected para‐Selective C–H bond Functionalizations

Angewandte Chemie International Edition, Accepted Article.
Regioselective C–H bond functionalization is pivotal in modern scientific exploration, offering solutions for achieving novel synthetic methodologies and pharmaceutical development. In this aspect, achieving exceptional regioselective functionalization, like para‐selective products in electron‐poor aromatics, diverges from traditional methods ...
Suman Pradhan, Jun Hu, Peng Ren, Yuman Qin, Noopur Jain, Susanna Monti, Giovanni Barcaro, Aleksander Jaworski, Xingchao Dai, Jabor Rabeah, Joaquin Silvestre-Albero, Veronica Celorrio, Anna Rokicińska, Piotr Kuśtrowski, Sandra Van Aert, Sara Bals, Shoubhik Das   +16 more
wiley   +1 more source

Iodine Deficiency Hypothyroidism Among Children in the United States - 21st Century Resurgence? [PDF]

AACE Clin Case Rep
Seetharaman S, Sasidharan Pillai S, Ganta A, Millington K, Quintos JB, Topor LS, Serrano-Gonzalez M.   +6 more
europepmc   +1 more source