Results 61 to 70 of about 32,086 (240)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

PancDS in Real‐World Practice: A Prospective Multicenter Validation of a Clinical Decision‐Support System Bridging Experience Gaps in Pancreatic Lesion Diagnosis

Advanced Science, EarlyView.
A biomimetic artificial intelligence system, PancDS, has been developed to distinguish pancreatic ductal adenocarcinoma from mass‐forming pancreatitis by adaptively integrating clinical data, radiomics, and deep learning features. Validated across multicenter, reader‐study, and prospective settings, PancDS improves diagnostic accuracy, particularly for
Zhibo Wang, Weinuo Qu, Wenwen Cai, Chuhuai Wang, Chenxi Lyu, Qingguo Xie, Qian Chu, Yaqi Shen, Peng Xiao, Feng Li, Qingpeng Zhang, Jiali Li, Jeong Min Lee, Zhen Li   +13 more
wiley   +1 more source

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

PREVENTION OF DISEASES RELATED TO IODINE DEFICIENCY IN GROUPS AT HIGH RISK OF ITS DEVELOPMENT: MODERN APPROACHES

Педиатрическая фармакология, 2010
The World Health Organization classifies pregnant and nursing women, as well as children under 2 years, as the group at increased risk of developing diseases related to iodine deficiency. Russia’s population experiences a chronic deficiency of iodine due
E.A. Troshina
doaj   +2 more sources

Sulfonated Bathocuproine Derivatives as Chemically Bonded Buried‐Interface Engineers for n–i–p Perovskite Solar Cells

Advanced Science, EarlyView.
A BCP‐derived buried‐interface strategy establishes Na‐BCS as a chemically bonded molecular bridge. By combining sulfonate anchoring to SnO2 with preserved BCP–Pb2+ coordination, Na‐BCS simultaneously passivates oxide‐ and perovskite‐side defects, suppresses non‐radiative recombination, and delivers a surface recombination velocity of 8.6 cm s−1, a ...
Dong Hyun Kim, Min Ju Jeong, SeungMin Lee, Oui Jin Oh, Mun Young Woo, Sung Yong Kim, Dong Hun Kang, Chan Young Kim, Chan Ho Shin, Jun Hong Noh   +9 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

CLINICAL AND ANAMNESTIC CHARACTERISTICS OF PREGNANT WOMEN WITH IODINE DEFICIENCY

Мать и дитя в Кузбассе, 2022
The aim of the research – the purpose of this work was to study of clinical and anamnestic characteristics of pregnant women with insufficient iodine supply, living in the region of natural mild iodine deficiency. Materials and methods.
Александр Николаевич Мацынин, Андрей Викторович Чурилов, Андрей Васильевич Налетов, Игорь Витальевич Коктышев   +3 more
doaj  

Iodine status of Saint Petersburg adult residents

Клиническая и экспериментальная тиреоидология, 2018
Backgraund. Globally, it is estimated that 2 billion individuals have an insufficient iodine intake. Aim. To assess iodine status and the effectiveness of iodine deficiency prophylaxis in adult population of St. Petersburg. Methods. А retrospective
Darya E. Soboleva, Svetlana V. Dora, Tatyana L. Karonova, Anna R. Volkova, Elena N. Grineva   +4 more
doaj   +1 more source

Strain Tuning the Occupation of Candidate Topological Weyl States in W‐Doped MoTe2

Advanced Science, EarlyView.
The present study investigates strain‐induced modifications of the electronic structure in the Weyl semimetal Td${\rm T}_d$‐Mo0.91W0.09Te2${\mathrm{Mo}}_{0.91}{\mathrm{W}}_{0.09}{\mathrm{Te}}_{2}$ using hard X‐ray angle‐resolved photoemission spectroscopy.
Amon Lanz, Olena Tkach, Yaryna Lytvynenko, Florian Diekmann, Harshit Agarwal, Sofia Michaela Souliou, Mehdi Frachet, Michael Merz, Sergii V. Chernov, Andrei Gloskovskii, Volkmar Koller, Dmytro Kutnyakhov, Moritz Hoesch, Christoph Schlueter, Philipp Rüssmann, Yuriy Mokrousov, Matthieu Le Tacon, Kai Rossnagel, Jure Demsar, Gerd Schönhense, Hans‐Joachim Elmers, Olena Fedchenko   +21 more
wiley   +1 more source