Results 31 to 40 of about 552 (164)

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Deficiency and excess of groundwater iodine and their health associations

Nature Communications, 2022
Both iodine deficiency and excess could cause thyroid disorders. By creating a national map of groundwater iodine throughout China, the authors reveal the spatial responses of diverse health risks to iodine in continental groundwater.
Ruoqi Ma, Mingquan Yan, Peng Han, Ting Wang, Bin Li, Shungui Zhou, Tong Zheng, Yandi Hu, Alistair G. L. Borthwick, Chunmiao Zheng, Jinren Ni   +10 more
doaj   +1 more source

Targeted‐Penetrating Biomimetic Hybrid Transfersomes for Enhanced Transdermal Gene Transfection in Hypertrophic Scar Therapy

Advanced Science, EarlyView.
Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing, Ziyi Zhao, Yuhui Yang, Yichen Lin, Yinglin Xuan, Ziyang Wang, Kai Lv, Xiaoxu Zhu, Zhi Zhang, Dong Ma   +9 more
wiley   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Iodine status in late pregnancy and psychosocial determinants of iodized salt use in rural northern Viet Nam

Bulletin of the World Health Organization, 2011
OBJECTIVE: To establish iodine status among pregnant women in rural northern Viet Nam and explore psychosocial predictors of the use of iodized salt in their households.
Jane Fisher, Thach Tran, Beverley Biggs, Tuan Tran, Terry Dwyer, Gerard Casey, Dang Hai Tho, Basil Hetze   +7 more
doaj  

The biological role of iodine and iodine deficiency as pathogenetic factor of thyroid pathology in pregnant women and its prevention

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
The article presents the most important information about the role of iodine in biological nature, its participation in different biological processes, formation of thyroid hormones and their effects on different organs and cells. Much attention is given
V.I. Kravchenko, B.K. Medvedev
doaj   +1 more source

Acinar‐Derived Organoids Reveal Stage‐Specific Control of Acinar Plasticity

Advanced Science, EarlyView.
An acinar‐derived organoid system maintains adult pancreatic acinar identity ex vivo, converts it along an ordered acinar‐to‐ductal‐like trajectory, and then partially restores it. Each transition carries its own signal requirement, with EGF/EGFR initiating conversion and a staged glucocorticoid–IGF1R switch driving redifferentiation.
Yongfei Hou, Siyu Li, Chunying Li, Zhifan Lin, Dan He, Li Yang, Liping Fu, Qianyue Zhang, Tianping Zhou, Yao Yao, Xiaolei Yin   +10 more
wiley   +1 more source

Iodine Deficiency Disorders Continue to be a Problem in the Asia Pacific Region

Journal of the ASEAN Federation of Endocrine Societies, 2014
Iodine deficiency disorders (IDD) due to inadequate dietary iodine is one of the major non-communicable diseases yet to be eliminated from our world, particularly in the Asia Pacific region.
Creswell J. Eastman
doaj  

Problem of Iodine Sufficiency in Republic of Belarus: Results of Introduction of Strategy to Control Iodine Deficiency

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
The results of introduction of strategy to control iodine deficiency in Republic of Belarus allowed the International Council for Control of Iodine Deficiency Disorders and Iodine Global Network to enter Belarus into the list of countries that attained ...
Т.V. Моkhort, N.D. Коlomiets, S.V. Petrenko, Е.V. Fеdorenko, А.P. Shеpеlkevich, А.V. Sоlntseva   +5 more
doaj   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source